Comparison of various UHMWPE formulations from contemporary total knee replacements before and after accelerated aging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00617860" target="_blank" >RIV/61389013:_____/25:00617860 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10496282 RIV/00216208:11310/25:10496282 RIV/00064203:_____/25:10496282

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0264127525002151?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264127525002151?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matdes.2025.113795" target="_blank" >10.1016/j.matdes.2025.113795</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of various UHMWPE formulations from contemporary total knee replacements before and after accelerated aging

Popis výsledku v původním jazyce

We have collected 21 different formulations of ultrahigh molecular weight polyethylene (UHMWPE), which have been employed as liners in contemporary total knee replacements (TKR). The UHMWPE liners were bought from the most important manufacturers on the orthopedic market in the Czech Republic as of 2020. The collected liners represented a broad range of both traditional and modern UHMWPE formulations, which differed by the level of crosslinking, type of thermal treatment, sterilization and/or stabilization. All obtained UHMWPE’s were characterized by multiple methods immediately after purchase and after the accelerated aging in H2O2. The experimental results (oxidative degradation, structure changes, and micromechanical properties) were correlated with manufacturer’s data (crosslinking, thermal treatment, sterilization, and stabilization). The investigated UHMWPE liners exhibited significant differences in their properties, namely in their resistance to long term oxidative degradation. The stiffness-related mechanical properties showed a strong correlation with the overall crystallinity. The crystallinity depended mostly on the oxidative degradation of the UHMWPE liners, while the thermal treatment played a minor role. The highest resistance to oxidation and wear, which promises the best in vivo performance, was found for the crosslinked UHMWPE formulations with biocompatible stabilizers (such as α-tocopherol, which is the key component of vitamin E).

Název v anglickém jazyce

Comparison of various UHMWPE formulations from contemporary total knee replacements before and after accelerated aging

Popis výsledku anglicky

We have collected 21 different formulations of ultrahigh molecular weight polyethylene (UHMWPE), which have been employed as liners in contemporary total knee replacements (TKR). The UHMWPE liners were bought from the most important manufacturers on the orthopedic market in the Czech Republic as of 2020. The collected liners represented a broad range of both traditional and modern UHMWPE formulations, which differed by the level of crosslinking, type of thermal treatment, sterilization and/or stabilization. All obtained UHMWPE’s were characterized by multiple methods immediately after purchase and after the accelerated aging in H2O2. The experimental results (oxidative degradation, structure changes, and micromechanical properties) were correlated with manufacturer’s data (crosslinking, thermal treatment, sterilization, and stabilization). The investigated UHMWPE liners exhibited significant differences in their properties, namely in their resistance to long term oxidative degradation. The stiffness-related mechanical properties showed a strong correlation with the overall crystallinity. The crystallinity depended mostly on the oxidative degradation of the UHMWPE liners, while the thermal treatment played a minor role. The highest resistance to oxidation and wear, which promises the best in vivo performance, was found for the crosslinked UHMWPE formulations with biocompatible stabilizers (such as α-tocopherol, which is the key component of vitamin E).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials and Design

ISSN

0264-1275

e-ISSN

1873-4197

Svazek periodika

252

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

113795

Kód UT WoS článku

001443777000001

EID výsledku v databázi Scopus

2-s2.0-86000297173