Effect of side groups on the surface parameters and antifouling properties of poly(N-alkyl acrylamide)-coated surfaces

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00637795" target="_blank" >RIV/61389013:_____/25:00637795 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/25:10500111

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/macp.202400481" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/macp.202400481</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/macp.202400481" target="_blank" >10.1002/macp.202400481</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of side groups on the surface parameters and antifouling properties of poly(N-alkyl acrylamide)-coated surfaces

Popis výsledku v původním jazyce

Understanding the origins of antifouling properties in polymer materials is essential for improving their biocompatibility. In this work, the effect of side groups in poly(N-alkyl acrylamide)s on their resistance to non-specific interactions with blood proteins is studied. Using reversible addition-fragmentation chain transfer (RAFT) polymerization protocol, a library of acrylamide-based polymers is synthesized, including poly((N-propyl)acrylamide) (pPAM), poly((N-ethyl)acrylamide) (pEAM), poly(N-(2-fluoroethyl)acrylamide) (pFEAM) and poly(N-(2-hydroxyethyl)acrylamide) (pHEAM), with four distinct chain lengths, i.e. degrees of polymerization (DP = 25, 50, 75, and 100). The polymer chains are attached to gold substrates under the most widely used “grafting to” approach through the trithiocarbonate chain end groups. The physical properties of the resulting polymer coatings are studied and evaluated their antifouling properties against blood plasma. While the of pPAM and pEAM reduced the fouling to a certain extent, semi-fluorinated pFEAM and pHEAM coatings showed improved fouling resistance with increasing DP and enhanced brush-like character. Notably, pFEAM and pHEAM coatings of nominal DP = 100 manage to reduce the fouling by more than 90% when compared to bare gold surfaces. These findings highlight the critical role of polymer side groups and chain length in designing antifouling coatings.

Název v anglickém jazyce

Effect of side groups on the surface parameters and antifouling properties of poly(N-alkyl acrylamide)-coated surfaces

Popis výsledku anglicky

Understanding the origins of antifouling properties in polymer materials is essential for improving their biocompatibility. In this work, the effect of side groups in poly(N-alkyl acrylamide)s on their resistance to non-specific interactions with blood proteins is studied. Using reversible addition-fragmentation chain transfer (RAFT) polymerization protocol, a library of acrylamide-based polymers is synthesized, including poly((N-propyl)acrylamide) (pPAM), poly((N-ethyl)acrylamide) (pEAM), poly(N-(2-fluoroethyl)acrylamide) (pFEAM) and poly(N-(2-hydroxyethyl)acrylamide) (pHEAM), with four distinct chain lengths, i.e. degrees of polymerization (DP = 25, 50, 75, and 100). The polymer chains are attached to gold substrates under the most widely used “grafting to” approach through the trithiocarbonate chain end groups. The physical properties of the resulting polymer coatings are studied and evaluated their antifouling properties against blood plasma. While the of pPAM and pEAM reduced the fouling to a certain extent, semi-fluorinated pFEAM and pHEAM coatings showed improved fouling resistance with increasing DP and enhanced brush-like character. Notably, pFEAM and pHEAM coatings of nominal DP = 100 manage to reduce the fouling by more than 90% when compared to bare gold surfaces. These findings highlight the critical role of polymer side groups and chain length in designing antifouling coatings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular Chemistry and Physics

ISSN

1022-1352

e-ISSN

1521-3935

Svazek periodika

226

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

70001

Kód UT WoS článku

001483301900001

EID výsledku v databázi Scopus

2-s2.0-105004689871