Hybrid thermoresponsive kappa-carrageenan-based polymer nanogels respond differently to mono- and divalent metal cations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F25%3A00641087" target="_blank" >RIV/61389013:_____/25:00641087 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0167732225019592?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167732225019592?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molliq.2025.128782" target="_blank" >10.1016/j.molliq.2025.128782</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hybrid thermoresponsive kappa-carrageenan-based polymer nanogels respond differently to mono- and divalent metal cations

Popis výsledku v původním jazyce

We investigated the stimuli-responsive behavior of hybrid κ-carrageenan-based polymers grafted with poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline) (POX), focusing on how these polymers respond simultaneously to mono- and divalent metal cations as well as changes in temperature. The aim of this study was to explore their potential for biological and radiopharmaceutical applications, where their responsiveness to specific stimuli is crucial. To achieve this, we used dynamic light scattering and small-angle X-ray scattering as key methodologies. We examined how the length and density of POX grafts influenced the polymers' solubility transitions and formation of nanogel clusters. Our results showed that shorter POX grafts resulted in smaller nanogel clusters, with graft length having a more significant effect on particle size compared to graft density. In addition, polymers with shorter grafts exhibited a higher temperature at which solubility changes occurred. The study also examines the effects of metal ions (Na+, K+, Rb+, Ca2+, and Sr2+) on the nanogel structure. We found that the fractal dimension of the clusters decreased for K+ and Ca2+ when the POX groups lost their solubility above the lower critical solution temperature (LCST), whereas it remained stable for Na+. Our findings highlight the complex molecular interactions and stimulus-responsivity cross-talks that govern the stimulus-responsive behavior of these hybrid copolymers. Understanding these interactions opens up avenues for future applications.

Název v anglickém jazyce

Hybrid thermoresponsive kappa-carrageenan-based polymer nanogels respond differently to mono- and divalent metal cations

Popis výsledku anglicky

We investigated the stimuli-responsive behavior of hybrid κ-carrageenan-based polymers grafted with poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline) (POX), focusing on how these polymers respond simultaneously to mono- and divalent metal cations as well as changes in temperature. The aim of this study was to explore their potential for biological and radiopharmaceutical applications, where their responsiveness to specific stimuli is crucial. To achieve this, we used dynamic light scattering and small-angle X-ray scattering as key methodologies. We examined how the length and density of POX grafts influenced the polymers' solubility transitions and formation of nanogel clusters. Our results showed that shorter POX grafts resulted in smaller nanogel clusters, with graft length having a more significant effect on particle size compared to graft density. In addition, polymers with shorter grafts exhibited a higher temperature at which solubility changes occurred. The study also examines the effects of metal ions (Na+, K+, Rb+, Ca2+, and Sr2+) on the nanogel structure. We found that the fractal dimension of the clusters decreased for K+ and Ca2+ when the POX groups lost their solubility above the lower critical solution temperature (LCST), whereas it remained stable for Na+. Our findings highlight the complex molecular interactions and stimulus-responsivity cross-talks that govern the stimulus-responsive behavior of these hybrid copolymers. Understanding these interactions opens up avenues for future applications.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Molecular Liquids

ISSN

0167-7322

e-ISSN

1873-3166

Svazek periodika

440

Číslo periodika v rámci svazku

15 December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

128782

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-105021039268