Evaluation of traditionally used medicinal plants for anticancer, antioxidant, anti-inflammatory and anti-viral (HPV-1) activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00479188" target="_blank" >RIV/61389030:_____/17:00479188 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.sajb.2017.05.021" target="_blank" >http://dx.doi.org/10.1016/j.sajb.2017.05.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sajb.2017.05.021" target="_blank" >10.1016/j.sajb.2017.05.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of traditionally used medicinal plants for anticancer, antioxidant, anti-inflammatory and anti-viral (HPV-1) activity

Popis výsledku v původním jazyce

The aim of this study was to determine the anticancer, antioxidant, anti-inflammatory and antiviral activities of traditionally used medicinal plants. The extracts were tested for cytotoxicity against human melanoma (A375), epidermoid carcinoma (A431), cervical epithelial carcinoma (HeLa) and human embryonic kidney cells (HEK-293). The antioxidant and anti-inflammatory activities were also determined. Gomphocarpus fruticosus, Helichrysum kraussii and Syzygium jambos were selected for activity against the herpes simplex virus type-1. The extracts exhibited low toxicity towards HEK-293 cells, and four extracts, namely Acacia mellifera, G. fruticosus, H. kraussii and S. jambos, were able to inhibit the A431 and HeLa cells with 50% inhibitory concentrations (IC 50 ) ranging from 34.90–56.20 μg/ml. Arbutus unedo, Combretum molle, Dissotis princeps, Erythrophleum lasianthum, Harpephyllum caffrum, H. kraussii and S. jambos, showed high DPPH inhibitory activity, with IC 50 values ranging from 2.41–5.25 μg/ml. The highest antioxidant activity was seen for S. jambos (DPPH) and A. unedo (NO) respectively with greater activity than ascorbic acid. D. princeps, H. caffrum, Leucas martinicensis and S. jambos, showed high inhibition of the cyclooxygenase-2 (COX-2) enzyme with IC 50 values ranging from 3.79–25.80 μg/ml with S. jambos showing the highest activity. S. jambos further showed the highest anti-HSV-1 activity at 50.00 μg/ml against 100TCID 50 virus challenge dose. This is the first report of the selected plants for their cytotoxicity, anti-inflammatory and viral inhibitory activity. S. jambos was able to show high inhibition of the HPV type-1 virus and the COX-2 enzyme.

Název v anglickém jazyce

Evaluation of traditionally used medicinal plants for anticancer, antioxidant, anti-inflammatory and anti-viral (HPV-1) activity

Popis výsledku anglicky

The aim of this study was to determine the anticancer, antioxidant, anti-inflammatory and antiviral activities of traditionally used medicinal plants. The extracts were tested for cytotoxicity against human melanoma (A375), epidermoid carcinoma (A431), cervical epithelial carcinoma (HeLa) and human embryonic kidney cells (HEK-293). The antioxidant and anti-inflammatory activities were also determined. Gomphocarpus fruticosus, Helichrysum kraussii and Syzygium jambos were selected for activity against the herpes simplex virus type-1. The extracts exhibited low toxicity towards HEK-293 cells, and four extracts, namely Acacia mellifera, G. fruticosus, H. kraussii and S. jambos, were able to inhibit the A431 and HeLa cells with 50% inhibitory concentrations (IC 50 ) ranging from 34.90–56.20 μg/ml. Arbutus unedo, Combretum molle, Dissotis princeps, Erythrophleum lasianthum, Harpephyllum caffrum, H. kraussii and S. jambos, showed high DPPH inhibitory activity, with IC 50 values ranging from 2.41–5.25 μg/ml. The highest antioxidant activity was seen for S. jambos (DPPH) and A. unedo (NO) respectively with greater activity than ascorbic acid. D. princeps, H. caffrum, Leucas martinicensis and S. jambos, showed high inhibition of the cyclooxygenase-2 (COX-2) enzyme with IC 50 values ranging from 3.79–25.80 μg/ml with S. jambos showing the highest activity. S. jambos further showed the highest anti-HSV-1 activity at 50.00 μg/ml against 100TCID 50 virus challenge dose. This is the first report of the selected plants for their cytotoxicity, anti-inflammatory and viral inhibitory activity. S. jambos was able to show high inhibition of the HPV type-1 virus and the COX-2 enzyme.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

South African Journal of Botany

ISSN

0254-6299

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

SEP

Stát vydavatele periodika

ZA - Jihoafrická republika

Počet stran výsledku

7

Strana od-do

494-500

Kód UT WoS článku

000410624200058

EID výsledku v databázi Scopus

2-s2.0-85019664011