Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F17%3A00481221" target="_blank" >RIV/61389030:_____/17:00481221 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/17:73584363

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.steroids.2017.08.010" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2017.08.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.steroids.2017.08.010" target="_blank" >10.1016/j.steroids.2017.08.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study

Popis výsledku v původním jazyce

A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 using AutoDock Vina. Plant growth promoting activity was measured using the pea inhibition biotest and Arabidopsis root sensitivity assay and then was compared with naturally occuring brassinosteroids. Differences in the production of plant hormone ethylene were also observed in etiolated pea seedlings after treatment with the new and also five known brassinosteroid phenyl analogues. Antiproliferative activity was also studied using normal human fibroblast and human cancer cell lines.

Název v anglickém jazyce

Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study

Popis výsledku anglicky

A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 using AutoDock Vina. Plant growth promoting activity was measured using the pea inhibition biotest and Arabidopsis root sensitivity assay and then was compared with naturally occuring brassinosteroids. Differences in the production of plant hormone ethylene were also observed in etiolated pea seedlings after treatment with the new and also five known brassinosteroid phenyl analogues. Antiproliferative activity was also studied using normal human fibroblast and human cancer cell lines.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Steroids

ISSN

0039-128X

e-ISSN

—

Svazek periodika

127

Číslo periodika v rámci svazku

NOV

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

46-55

Kód UT WoS článku

000413607900007

EID výsledku v databázi Scopus

2-s2.0-85028510908