Synthesis and biological activity of brassinosteroid analogues with a nitrogen-containing side chain

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F21%3A00543685" target="_blank" >RIV/61389030:_____/21:00543685 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/21:73605204

Výsledek na webu

<a href="http://doi.org/10.3390/ijms22010155" target="_blank" >http://doi.org/10.3390/ijms22010155</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms22010155" target="_blank" >10.3390/ijms22010155</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and biological activity of brassinosteroid analogues with a nitrogen-containing side chain

Popis výsledku v původním jazyce

Brassinosteroids are a class of plant hormones that regulate a broad range of physiological processes such as plant growth, development and immunity, including the suppression of biotic and abiotic stresses. In this paper, we report the synthesis of new brassinosteroid analogues with a nitrogen-containing side chain and their biological activity on Arabidopis thaliana. Based on molecular docking experiments, two groups of brassinosteroid analogues were prepared with short and long side chains in order to study the impact of side chain length on plants. the derivatives with a short side chain were prepared with amide, amine and ammonium functional groups. the derivatives with a long side chain were synthesized using amide and ammonium functional groups. A total of 25 new brassinosteroid analogues were prepared. All 25 compounds were tested in an Arabidopsis root sensitivity bioassay and cytotoxicity screening. the synthesized substances showed no signifi-cant inhibitory activity compared to natural 24-epibrassinolide. In contrast, in low concentration, several compounds (8a, 8b, 8e, 16e, 22a and 22e) showed interesting growth-promoting activity. the cytotoxicity assay showed no toxicity of the prepared compounds on cancer and normal cell lines.

Název v anglickém jazyce

Synthesis and biological activity of brassinosteroid analogues with a nitrogen-containing side chain

Popis výsledku anglicky

Brassinosteroids are a class of plant hormones that regulate a broad range of physiological processes such as plant growth, development and immunity, including the suppression of biotic and abiotic stresses. In this paper, we report the synthesis of new brassinosteroid analogues with a nitrogen-containing side chain and their biological activity on Arabidopis thaliana. Based on molecular docking experiments, two groups of brassinosteroid analogues were prepared with short and long side chains in order to study the impact of side chain length on plants. the derivatives with a short side chain were prepared with amide, amine and ammonium functional groups. the derivatives with a long side chain were synthesized using amide and ammonium functional groups. A total of 25 new brassinosteroid analogues were prepared. All 25 compounds were tested in an Arabidopsis root sensitivity bioassay and cytotoxicity screening. the synthesized substances showed no signifi-cant inhibitory activity compared to natural 24-epibrassinolide. In contrast, in low concentration, several compounds (8a, 8b, 8e, 16e, 22a and 22e) showed interesting growth-promoting activity. the cytotoxicity assay showed no toxicity of the prepared compounds on cancer and normal cell lines.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

1422-0067

Svazek periodika

22

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

27

Strana od-do

155

Kód UT WoS článku

000606229400001

EID výsledku v databázi Scopus

2-s2.0-85098771484