Biological activities of extract from Coleonema album in vitro

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00510007" target="_blank" >RIV/61389030:_____/19:00510007 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.sajb.2019.06.015" target="_blank" >http://dx.doi.org/10.1016/j.sajb.2019.06.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sajb.2019.06.015" target="_blank" >10.1016/j.sajb.2019.06.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biological activities of extract from Coleonema album in vitro

Popis výsledku v původním jazyce

Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method.

Název v anglickém jazyce

Biological activities of extract from Coleonema album in vitro

Popis výsledku anglicky

Coleonema album is a South African shrub which is used as an anti-inflammatory. A methanolic leaf extract of C. album was here tested in vitro in various anti-inflammatory assays to establish a possible mode of action, as well as for cytotoxicity. The C. album extract did not change the signaling of anti-inflammatory activity in vitro. The extract inhibited COX-1, COX-2 and IL-6, but not ELAM or ICAM-1. Pellitorine, an alkamide isolated and identified from C. album, did not show any activity in the anti-inflammatory assays. The extract showed no cytotoxicity in normal and cancer cell lines. Finally, pellitorine was identified in C. album by UHPLC-QTOF-MS and its concentration was determined by an external standard method.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

South African Journal of Botany

ISSN

0254-6299

e-ISSN

—

Svazek periodika

126

Číslo periodika v rámci svazku

NOV

Stát vydavatele periodika

ZA - Jihoafrická republika

Počet stran výsledku

6

Strana od-do

176-181

Kód UT WoS článku

000489157200020

EID výsledku v databázi Scopus

2-s2.0-85068470824