The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-alpha secretion and cyclooxygenase activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875917" target="_blank" >RIV/62157124:16370/17:43875917 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00098458

Výsledek na webu

<a href="http://dx.doi.org/10.2754/avb201786030223" target="_blank" >http://dx.doi.org/10.2754/avb201786030223</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb201786030223" target="_blank" >10.2754/avb201786030223</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-alpha secretion and cyclooxygenase activity

Popis výsledku v původním jazyce

Quaternary benzophenanthridine alkaloids are known to have a wide range of biological effects, including antimicrobial, antifungal, anti-inflammatory, and antitumour activities. The anti-inflammatory potential of the chosen alkaloids was evaluated as for their ability to modulate the lipopolysaccharide-induced secretion of tumour necrosis factor alpha (TNF-alpha) in the macrophage-like cell line THP-1. The cyclooxygenase (COX)-1 and COX-2 inhibitory activities were also measured. The results indicate that the presence of a methylenedioxy ring attached at carbon (C) 7-C8 is important for reducing the secretion of TNF-alpha. Interestingly, this effect did not show a simple dependence on concentration. The selected alkaloids showed little or no anti-COX activity. The results obtained from the present experiments may provide additional information useful in understanding the structure-to-activity relationship of the quaternary benzophenanthridine alkaloids. The anti-inflammatory potential and the cytotoxic effect are driven by the presence of a methylenedioxy ring attached at C7-C8 and C2-C3, respectively.

Název v anglickém jazyce

The capability of minor quaternary benzophenanthridine alkaloids to inhibit TNF-alpha secretion and cyclooxygenase activity

Popis výsledku anglicky

Quaternary benzophenanthridine alkaloids are known to have a wide range of biological effects, including antimicrobial, antifungal, anti-inflammatory, and antitumour activities. The anti-inflammatory potential of the chosen alkaloids was evaluated as for their ability to modulate the lipopolysaccharide-induced secretion of tumour necrosis factor alpha (TNF-alpha) in the macrophage-like cell line THP-1. The cyclooxygenase (COX)-1 and COX-2 inhibitory activities were also measured. The results indicate that the presence of a methylenedioxy ring attached at carbon (C) 7-C8 is important for reducing the secretion of TNF-alpha. Interestingly, this effect did not show a simple dependence on concentration. The selected alkaloids showed little or no anti-COX activity. The results obtained from the present experiments may provide additional information useful in understanding the structure-to-activity relationship of the quaternary benzophenanthridine alkaloids. The anti-inflammatory potential and the cytotoxic effect are driven by the presence of a methylenedioxy ring attached at C7-C8 and C2-C3, respectively.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

—

Svazek periodika

86

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

223-230

Kód UT WoS článku

000416306200004

EID výsledku v databázi Scopus

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