Anti-cancer activities of cytokinin ribosides
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F19%3A00512141" target="_blank" >RIV/61389030:_____/19:00512141 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/19:73598612 RIV/61989592:15310/19:73598612
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11101-019-09620-4" target="_blank" >http://dx.doi.org/10.1007/s11101-019-09620-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11101-019-09620-4" target="_blank" >10.1007/s11101-019-09620-4</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Anti-cancer activities of cytokinin ribosides
Popis výsledku v původním jazyce
Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived from diverse malignancies including those with a mutant p53 gene. Activity against cancer stem cells, anti-angiogenic activity, and the ability to stimulate an immune response to malignant cells have been reported as well. There are also positive results from in vivo studies and reports of activity in patients with hematological malignancies and solid tumors. Here, we review studies of the anti-cancer activity of cytokinin ribosides since the 1960s and comment on the issues that need to be addressed for the further development of cytokinin ribosides into anti-cancer drugs.
Název v anglickém jazyce
Anti-cancer activities of cytokinin ribosides
Popis výsledku anglicky
Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived from diverse malignancies including those with a mutant p53 gene. Activity against cancer stem cells, anti-angiogenic activity, and the ability to stimulate an immune response to malignant cells have been reported as well. There are also positive results from in vivo studies and reports of activity in patients with hematological malignancies and solid tumors. Here, we review studies of the anti-cancer activity of cytokinin ribosides since the 1960s and comment on the issues that need to be addressed for the further development of cytokinin ribosides into anti-cancer drugs.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Phytochemistry Reviews
ISSN
1568-7767
e-ISSN
—
Svazek periodika
18
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
13
Strana od-do
1101-1113
Kód UT WoS článku
000496695300007
EID výsledku v databázi Scopus
2-s2.0-85068869146