Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389030%3A_____%2F23%3A00575713" target="_blank" >RIV/61389030:_____/23:00575713 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/23:73622977

Výsledek na webu

<a href="https://doi.org/10.1016/j.sajb.2023.05.030" target="_blank" >https://doi.org/10.1016/j.sajb.2023.05.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sajb.2023.05.030" target="_blank" >10.1016/j.sajb.2023.05.030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

Popis výsledku v původním jazyce

Diabetes mellitus (DM) is a chronic metabolic dysfunction characterised by hyperglycaemia. It is strongly linked to oxidative stress. Post-meal elevation of blood glucose levels predisposes humans to Type 2 DM. Retardation of the digestive enzymes α-glucosidase and α-amylase is an efficient therapeutic approach to regulate hyperglycaemia. Many indigenous plants are commonly used in managing DM. However, most of these claims have not been verified scientifically. This study investigated eleven indigenous South African plants for their antioxidant and hypoglycaemic potentials. The phytochemical content (total phenolics, flavonoids and condensed tannins) was quantified colormetrically. The antioxidant potential of crude leaf extracts was evaluated against ferric-reducing antioxidant power (FRAP) and 1,1-Diphenyl-2-picrylhydrazyl (DPPH•). In vitro inhibition of digestive enzymes (α-amylase and α-glucosidase) by the extracts were used to evaluate their antidiabetic activities. Six of the plant species investigated, namely, Catha edulis, Combretum kraussii, Lippia javanica, Endostemon obtusifolius, Psidium guajava and Syzygium cordatum had significant concentrations of flavonoids, total phenolics and/or condensed tannins. These six plant species generally demonstrated significantly lower IC50 values than the positive controls (butylated hydroxyl-toluene (BHT) and acarbose) in the in vitro antioxidant and antidiabetic assays. These results support the use of some of the investigated traditional plants in DM management. The antidiabetic potential of E. obtusifolius, a relatively under-utilized plant, as well as C. kraussii and C. edulis were highlighted as promising species for further investigation as hypoglycaemic agents.

Název v anglickém jazyce

Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants

Popis výsledku anglicky

Diabetes mellitus (DM) is a chronic metabolic dysfunction characterised by hyperglycaemia. It is strongly linked to oxidative stress. Post-meal elevation of blood glucose levels predisposes humans to Type 2 DM. Retardation of the digestive enzymes α-glucosidase and α-amylase is an efficient therapeutic approach to regulate hyperglycaemia. Many indigenous plants are commonly used in managing DM. However, most of these claims have not been verified scientifically. This study investigated eleven indigenous South African plants for their antioxidant and hypoglycaemic potentials. The phytochemical content (total phenolics, flavonoids and condensed tannins) was quantified colormetrically. The antioxidant potential of crude leaf extracts was evaluated against ferric-reducing antioxidant power (FRAP) and 1,1-Diphenyl-2-picrylhydrazyl (DPPH•). In vitro inhibition of digestive enzymes (α-amylase and α-glucosidase) by the extracts were used to evaluate their antidiabetic activities. Six of the plant species investigated, namely, Catha edulis, Combretum kraussii, Lippia javanica, Endostemon obtusifolius, Psidium guajava and Syzygium cordatum had significant concentrations of flavonoids, total phenolics and/or condensed tannins. These six plant species generally demonstrated significantly lower IC50 values than the positive controls (butylated hydroxyl-toluene (BHT) and acarbose) in the in vitro antioxidant and antidiabetic assays. These results support the use of some of the investigated traditional plants in DM management. The antidiabetic potential of E. obtusifolius, a relatively under-utilized plant, as well as C. kraussii and C. edulis were highlighted as promising species for further investigation as hypoglycaemic agents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

South African Journal of Botany

ISSN

0254-6299

e-ISSN

1727-9321

Svazek periodika

159

Číslo periodika v rámci svazku

AUG

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

686-696

Kód UT WoS článku

001044967700001

EID výsledku v databázi Scopus

2-s2.0-85165054762