Rozdíly mezi předepisovanými denními dávkami a definovanými denními dávkami antiepileptik - terapeutické monitorování jako marker kvality terapie

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F06%3AA0900JCG" target="_blank" >RIV/61988987:17110/06:A0900JCG - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Differences between prescribed daily doses and defined daily doses of antiepileptics-therapeutic drug monitoring as a marker of the quality of the treatment.

Popis výsledku v původním jazyce

Objective: Prescribed daily doses (PDDs) of antiepileptics (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospital in Ostrava, Czechia. Plasma levels were used as an indicator of the quality of treatment. Method: Request and reply forms for therapeutic drug monitoring (TDM) were used as a source of PDDs and plasma levels. Conclusions: PDDs in monotherapy were similar or slightly lower than in combination therapy with an exception for lamotrigine,NS. The differences were significant in carbamazepine, p &lt; 0.0001, and valproic acid, p &lt; 0.001. Patients with plasma levels within the therapeutic range were usually treated with similar or slightly higher doses than the remainder. In general plasma levels tended to be below the therapeutic range. The differences between PDD and DDD of antiepileptics have to be taken into account especially when utilization of different drugs is compared.

Název v anglickém jazyce

Differences between prescribed daily doses and defined daily doses of antiepileptics-therapeutic drug monitoring as a marker of the quality of the treatment.

Popis výsledku anglicky

Objective: Prescribed daily doses (PDDs) of antiepileptics (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospital in Ostrava, Czechia. Plasma levels were used as an indicator of the quality of treatment. Method: Request and reply forms for therapeutic drug monitoring (TDM) were used as a source of PDDs and plasma levels. Conclusions: PDDs in monotherapy were similar or slightly lower than in combination therapy with an exception for lamotrigine,NS. The differences were significant in carbamazepine, p &lt; 0.0001, and valproic acid, p &lt; 0.001. Patients with plasma levels within the therapeutic range were usually treated with similar or slightly higher doses than the remainder. In general plasma levels tended to be below the therapeutic range. The differences between PDD and DDD of antiepileptics have to be taken into account especially when utilization of different drugs is compared.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INT J CLIN PHARM TH

ISSN

0946-1965

e-ISSN

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Svazek periodika

44

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000240244500006

EID výsledku v databázi Scopus

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