Použití dat TDM pro stanovení validity DDD antiepileptik: srovnání mezi českou a švédskou fakultní nemocnicí

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F06%3AA0900JCF" target="_blank" >RIV/61988987:17110/06:A0900JCF - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Use of TDM Data to Asses teh Validity of Defined Daily Doses of Antiepileptics: A Comparison Between a Czech and Swedish University Hospital.

Popis výsledku v původním jazyce

Prescribed daily doses (PDDs) of antiepileptic drugs (AED) (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospitals in Ostrava, Czech Republic and Huddinge, Sweden. Plasma concentrations were usedas an indicator of the quality of treatment. The PDDs of most of the AEDs were lower than the DDDs. PDDs in monotherapy were only slightly lower than in combination therapy. Patients with plasma concentrations within the therapeutic range were usually treated with slightly higher doses than the remainder. In general, plasma concentrations tended to be in the low therapeutic range. The differences in PDDs between hospitals were significant in the case of valproic acid, phenobarbital (except monotherapywithin), vigabatrin, and gabapentin, and carbamazepine. Our data suggest that the DDDs of AEDs should be reconsidered as, in the majority of cases, they appear to be too high.

Název v anglickém jazyce

The Use of TDM Data to Asses teh Validity of Defined Daily Doses of Antiepileptics: A Comparison Between a Czech and Swedish University Hospital.

Popis výsledku anglicky

Prescribed daily doses (PDDs) of antiepileptic drugs (AED) (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospitals in Ostrava, Czech Republic and Huddinge, Sweden. Plasma concentrations were usedas an indicator of the quality of treatment. The PDDs of most of the AEDs were lower than the DDDs. PDDs in monotherapy were only slightly lower than in combination therapy. Patients with plasma concentrations within the therapeutic range were usually treated with slightly higher doses than the remainder. In general, plasma concentrations tended to be in the low therapeutic range. The differences in PDDs between hospitals were significant in the case of valproic acid, phenobarbital (except monotherapywithin), vigabatrin, and gabapentin, and carbamazepine. Our data suggest that the DDDs of AEDs should be reconsidered as, in the majority of cases, they appear to be too high.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

THER DRUG MONIT

ISSN

0163-4356

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000241347600003

EID výsledku v databázi Scopus

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