Hypocholesterolaemia on the medical intensive care unit: The process of cholesterol synthesis rption is altered in the acute phase of disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F09%3AA1000VSV" target="_blank" >RIV/61988987:17110/09:A1000VSV - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hypocholesterolaemia on the medical intensive care unit: The process of cholesterol synthesis rption is altered in the acute phase of disease

Popis výsledku v původním jazyce

The aim of this study is to describe the changes of cholesterol metabolism in patients with acute medical disease. The study included 60 patients with acute medical disease solely on artificial nutrition. Plasma concentrations of total cholesterol, HDL and LDL cholesterol were measured on days 0,3 and 7. Lathosterol, squalene, sitosterol and campesterol concentrations were determined on days 3 and 7. The metabolic parameters were compared with a control group.Results: We detected a statistically significant decrease in total chol.concentration, and lower plasma levels of LDL and HDL chol. A statistically significant decrease in lathosterol and campesterol plasma levels was detected. Sitosterol concentrations were lower but not significantly. The concentration of squalene was noted to be higher than in the control group.Concl.Our results show abnormalities in the chol.metabolism, including both arms of the cholesterol acquisition process, in patients with acute medical disease.

Název v anglickém jazyce

Hypocholesterolaemia on the medical intensive care unit: The process of cholesterol synthesis rption is altered in the acute phase of disease

Popis výsledku anglicky

The aim of this study is to describe the changes of cholesterol metabolism in patients with acute medical disease. The study included 60 patients with acute medical disease solely on artificial nutrition. Plasma concentrations of total cholesterol, HDL and LDL cholesterol were measured on days 0,3 and 7. Lathosterol, squalene, sitosterol and campesterol concentrations were determined on days 3 and 7. The metabolic parameters were compared with a control group.Results: We detected a statistically significant decrease in total chol.concentration, and lower plasma levels of LDL and HDL chol. A statistically significant decrease in lathosterol and campesterol plasma levels was detected. Sitosterol concentrations were lower but not significantly. The concentration of squalene was noted to be higher than in the control group.Concl.Our results show abnormalities in the chol.metabolism, including both arms of the cholesterol acquisition process, in patients with acute medical disease.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anest Int Med

ISSN

1214-2158

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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