Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F15%3AA1601FK4" target="_blank" >RIV/61988987:17110/15:A1601FK4 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

Popis výsledku v původním jazyce

Maternal and umbilical cord serum levels were analyzed at delivery in a cohort of 58 women, between the years 1991-2013. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios. Result. The levels varied from 5,3-59,5 mg/L in maternal and 5,4-72,1 mg/L in umbilical cordserum. The umbilical cord/maternal level ratios ranged from 0,64-2,49. Significant correlation was found between maternal and umbilical cord levels. Significant inverse correlations were found between birth length, and both maternal and umbilical cord levels in monotherapy.

Název v anglickém jazyce

Serum levels of valproic acid during delivery in mothers and in umbilical cord-correlation with birth length and weight

Popis výsledku anglicky

Maternal and umbilical cord serum levels were analyzed at delivery in a cohort of 58 women, between the years 1991-2013. The request forms for routine therapeutic drug monitoring were used as the data source. Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios. Result. The levels varied from 5,3-59,5 mg/L in maternal and 5,4-72,1 mg/L in umbilical cordserum. The umbilical cord/maternal level ratios ranged from 0,64-2,49. Significant correlation was found between maternal and umbilical cord levels. Significant inverse correlations were found between birth length, and both maternal and umbilical cord levels in monotherapy.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomed Pap Med Univ Palacky Olomouc

ISSN

1213-8118

e-ISSN

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Svazek periodika

159

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

569-575

Kód UT WoS článku

000366566700009

EID výsledku v databázi Scopus

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