Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in maternal and umbilical cord blood at birth:Influence of co-administration of valproic or enzyme-unducing antiepileptic drugs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F16%3AA1701GTO" target="_blank" >RIV/61988987:17110/16:A1701GTO - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in maternal and umbilical cord blood at birth:Influence of co-administration of valproic or enzyme-unducing antiepileptic drugs

Popis výsledku v původním jazyce

Carmbamazepine is one of the three most frequently prescribed antiepileptic frugs in pregnancy. However, data relating to both carbamazepine and carbamazepine-10, 11-epoxide transplacental passage remain sparse. We have analysed in a cohort of 114 women carbamazepine and carbamazepine-10, 11-epoxide levels in maternal and umbilical cord serum at birth during 25 years retrospectively. The data showed the wide interindividual variability of the ratio of the umbilical cord/maternal level of both carbamaziepine and carbamazepine-10,11-epoxide. it is the first study show-ing the significant increase of the ratio of umbilical cord/maternal level of carbamazepine-10, 11-epoxide and carbamazepine-10,11-epoxide/carbamazepine ratio not only in maternal serum but also in umbilical cord in addition of valproic acid. The present study demonstates thal a concomitant administration of enzyme-inducing antiepileptics and valproic acid increases the maternal apparent oral clearance of carbamazepine significantly.

Název v anglickém jazyce

Concentrations of carbamazepine and carbamazepine-10, 11-epoxide in maternal and umbilical cord blood at birth:Influence of co-administration of valproic or enzyme-unducing antiepileptic drugs

Popis výsledku anglicky

Carmbamazepine is one of the three most frequently prescribed antiepileptic frugs in pregnancy. However, data relating to both carbamazepine and carbamazepine-10, 11-epoxide transplacental passage remain sparse. We have analysed in a cohort of 114 women carbamazepine and carbamazepine-10, 11-epoxide levels in maternal and umbilical cord serum at birth during 25 years retrospectively. The data showed the wide interindividual variability of the ratio of the umbilical cord/maternal level of both carbamaziepine and carbamazepine-10,11-epoxide. it is the first study show-ing the significant increase of the ratio of umbilical cord/maternal level of carbamazepine-10, 11-epoxide and carbamazepine-10,11-epoxide/carbamazepine ratio not only in maternal serum but also in umbilical cord in addition of valproic acid. The present study demonstates thal a concomitant administration of enzyme-inducing antiepileptics and valproic acid increases the maternal apparent oral clearance of carbamazepine significantly.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EPILEPSY RES

ISSN

0920-1211

e-ISSN

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Svazek periodika

122

Číslo periodika v rámci svazku

May 01

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

84-90

Kód UT WoS článku

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EID výsledku v databázi Scopus

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