Carbon dioxide insufflation during colonoscopy in inflammatory bowel disease patients: A double-blind, randomized, single-center trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1701M1N" target="_blank" >RIV/61988987:17110/17:A1701M1N - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/17:N0000003

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pubmed/27845950" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/27845950</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MEG.0000000000000791" target="_blank" >10.1097/MEG.0000000000000791</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Carbon dioxide insufflation during colonoscopy in inflammatory bowel disease patients: A double-blind, randomized, single-center trial

Popis výsledku v původním jazyce

Objective Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO 2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO 2 insufflation have never been studied in inflammatory bowel disease (IBD) patients, characterized by younger age, structural changes of the colon, and need for repeated and frequently uncomfortable colonoscopies. Our trial was designed to evaluate postprocedural discomfort associated with CO 2 compared with air insufflation in unsedated or minimally sedated patients with known IBD. Methods In a double-blind, randomized, single-center study, 64 patients were randomized to either CO 2 insufflation (CO 2) or air insufflation colonoscopy (Air). Abdominal pain, bloating, and flatulence scores during 24 h after colonoscopy were recorded using a continuous scale of 0-10 (0=none, 10=maximum discomfort). The primary endpoint used for power calculation was bloating score at 1 h after colonoscopy. Results Pain, bloating, and flatulence scores at end, 1, and 3 h after colonoscopy were significantly lower in CO 2 than in Air arm (P<0.001). Scores at 6, 12, and 24 h were comparable. Procedural parameters such as cecal and terminal ileum intubation rate, intubation and total time, pain during insertion, need for repositioning, and abdominal compression were not different between arms. No complications were recorded in the study. Conclusion Compared with air, CO 2 insufflation significantly reduces abdominal pain, bloating, and flatulence scores during at least 3 h after colonoscopy in IBD patients, achieving comparable intraprocedural outcomes. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Název v anglickém jazyce

Carbon dioxide insufflation during colonoscopy in inflammatory bowel disease patients: A double-blind, randomized, single-center trial

Popis výsledku anglicky

Objective Bowel distension by insufflated air causes abdominal discomfort after colonoscopy. Carbon dioxide (CO 2) instead of air insufflation during colonoscopy can reduce postprocedural discomfort in diagnostic and screening cases. Discomfort after colonoscopy and CO 2 insufflation have never been studied in inflammatory bowel disease (IBD) patients, characterized by younger age, structural changes of the colon, and need for repeated and frequently uncomfortable colonoscopies. Our trial was designed to evaluate postprocedural discomfort associated with CO 2 compared with air insufflation in unsedated or minimally sedated patients with known IBD. Methods In a double-blind, randomized, single-center study, 64 patients were randomized to either CO 2 insufflation (CO 2) or air insufflation colonoscopy (Air). Abdominal pain, bloating, and flatulence scores during 24 h after colonoscopy were recorded using a continuous scale of 0-10 (0=none, 10=maximum discomfort). The primary endpoint used for power calculation was bloating score at 1 h after colonoscopy. Results Pain, bloating, and flatulence scores at end, 1, and 3 h after colonoscopy were significantly lower in CO 2 than in Air arm (P<0.001). Scores at 6, 12, and 24 h were comparable. Procedural parameters such as cecal and terminal ileum intubation rate, intubation and total time, pain during insertion, need for repositioning, and abdominal compression were not different between arms. No complications were recorded in the study. Conclusion Compared with air, CO 2 insufflation significantly reduces abdominal pain, bloating, and flatulence scores during at least 3 h after colonoscopy in IBD patients, achieving comparable intraprocedural outcomes. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EUR J GASTROEN HEPAT

ISSN

0954-691X

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

355-359

Kód UT WoS článku

000393773100018

EID výsledku v databázi Scopus

2-s2.0-84995466957