Brain Activity on fMRI Associated With Urinary Bladder Filling in Patients with a Complete Spinal Cord Injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801QOI" target="_blank" >RIV/61988987:17110/17:A1801QOI - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10359452 RIV/00216208:11120/17:43912820 RIV/00843989:_____/17:E0105800 RIV/00023001:_____/17:00060292 RIV/00064190:_____/17:N0000090

Výsledek na webu

<a href="http://dx.doi.org/10.1002/nau.22901" target="_blank" >http://dx.doi.org/10.1002/nau.22901</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/nau.22901" target="_blank" >10.1002/nau.22901</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain Activity on fMRI Associated With Urinary Bladder Filling in Patients with a Complete Spinal Cord Injury

Popis výsledku v původním jazyce

Objective: Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain activation arising from anticipated extraspinal sensory pathways. Methods: Fourteen patients ages 24-54 years were enrolled, all having experienced a complete SCI (ASIA A) at C7 to T5 an average of 17 months before study entry. Urodynamic equipment was used for repeated bladder filling and detrusor activity evaluation. All functional magnetic resonance imaging measurements were performed using a Siemens Trio 3T scanner with the GRE-EPI sequence (field of view = 192 x 192 mm, voxel 3 x 3 x 3 mm, TR/TE = 3000/30 ms, 45 slices). Nine hundred dynamic scans were acquired over 45 min. Statistical analysis was done in SPM8 using a general linear model. Statistics using t-tests were thresholded at P = 0.001. Results: We excluded results from two patients because of activation artifacts. In 8 of 12 patients, significant brain activity was observed during urinary bladder filling. We found significant activation clusters at the nucleus of the solitary tract (NTS) (3/8), parabrachial nucleus (PBN) (4/8), hypothalamus (4/8), thalamus (6/8), amygdala (7/8), insular lobe (5/8), anterior cingulate gyrus (5/8), and prefrontal cortex (8/8). Activations in nuclei involved in afferents likely from the vagal nerve (NTS and PBN) correlated significantly with reported bladder sensations. Conclusions: These data suggest that extraspinal sensory pathways may develop following SCI and that vagal nerve may play a role in re-innervation of the urinary bladder. (C) 2015 Wiley Periodicals, Inc.

Název v anglickém jazyce

Brain Activity on fMRI Associated With Urinary Bladder Filling in Patients with a Complete Spinal Cord Injury

Popis výsledku anglicky

Objective: Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain activation arising from anticipated extraspinal sensory pathways. Methods: Fourteen patients ages 24-54 years were enrolled, all having experienced a complete SCI (ASIA A) at C7 to T5 an average of 17 months before study entry. Urodynamic equipment was used for repeated bladder filling and detrusor activity evaluation. All functional magnetic resonance imaging measurements were performed using a Siemens Trio 3T scanner with the GRE-EPI sequence (field of view = 192 x 192 mm, voxel 3 x 3 x 3 mm, TR/TE = 3000/30 ms, 45 slices). Nine hundred dynamic scans were acquired over 45 min. Statistical analysis was done in SPM8 using a general linear model. Statistics using t-tests were thresholded at P = 0.001. Results: We excluded results from two patients because of activation artifacts. In 8 of 12 patients, significant brain activity was observed during urinary bladder filling. We found significant activation clusters at the nucleus of the solitary tract (NTS) (3/8), parabrachial nucleus (PBN) (4/8), hypothalamus (4/8), thalamus (6/8), amygdala (7/8), insular lobe (5/8), anterior cingulate gyrus (5/8), and prefrontal cortex (8/8). Activations in nuclei involved in afferents likely from the vagal nerve (NTS and PBN) correlated significantly with reported bladder sensations. Conclusions: These data suggest that extraspinal sensory pathways may develop following SCI and that vagal nerve may play a role in re-innervation of the urinary bladder. (C) 2015 Wiley Periodicals, Inc.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

<a href="/cs/project/NT14183" target="_blank" >NT14183: Mapování mozkové aktivity během plnění a vyprazdňování močového měchýře pomocí funkční magnetické rezonance</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurourology and Urodynamics

ISSN

0733-2467

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

155-159

Kód UT WoS článku

000394666500024

EID výsledku v databázi Scopus

2-s2.0-84949871150