Biomarkers in immunoglobulin light chain amyloidosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801R4R" target="_blank" >RIV/61988987:17110/17:A1801R4R - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14110/17:00098262 RIV/00216208:11110/17:10365703 RIV/65269705:_____/17:00067299 RIV/00843989:_____/17:E0106564 a 2 dalších
Výsledek na webu
<a href="http://dx.doi.org/10.14735/amko20172S60" target="_blank" >http://dx.doi.org/10.14735/amko20172S60</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14735/amko20172S60" target="_blank" >10.14735/amko20172S60</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biomarkers in immunoglobulin light chain amyloidosis
Popis výsledku v původním jazyce
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction. As amyloid depositing in target organs is irreversible, there is a big effort to identify bio marker that could help to distinguish ALA from other monoclonal gammopathies in the early stages of disease, when amyloid deposits are not fatal yet. High throughput technologies bring new opportunities to modern cancer research as they enable to study disease within its complexity. Sophisticated methods such as next generation sequencing, gene expression profiling and circulating microRNA profiling are new approaches to study aberrant plasma cells from patients with light chain amyloidosis and related diseases. While generally known mutation in multiple myeloma patients (KRAS, NRAS, MYC, TP53) were not found in ALA, number of mutated genes is comparable. Transcriptome of ALA patients proves to be more similar to monoclonal gammopathy of undetermined significance patients, moreover level of circulating microRNA, that are known to correlate with heart damage, is increased in ALA patients, where heart damage in ALA typical symptom.
Název v anglickém jazyce
Biomarkers in immunoglobulin light chain amyloidosis
Popis výsledku anglicky
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction. As amyloid depositing in target organs is irreversible, there is a big effort to identify bio marker that could help to distinguish ALA from other monoclonal gammopathies in the early stages of disease, when amyloid deposits are not fatal yet. High throughput technologies bring new opportunities to modern cancer research as they enable to study disease within its complexity. Sophisticated methods such as next generation sequencing, gene expression profiling and circulating microRNA profiling are new approaches to study aberrant plasma cells from patients with light chain amyloidosis and related diseases. While generally known mutation in multiple myeloma patients (KRAS, NRAS, MYC, TP53) were not found in ALA, number of mutated genes is comparable. Transcriptome of ALA patients proves to be more similar to monoclonal gammopathy of undetermined significance patients, moreover level of circulating microRNA, that are known to correlate with heart damage, is increased in ALA patients, where heart damage in ALA typical symptom.
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
30205 - Hematology
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Klinicka Onkologie
ISSN
0862-495X
e-ISSN
—
Svazek periodika
30
Číslo periodika v rámci svazku
13. 7. 2017
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
60-67
Kód UT WoS článku
—
EID výsledku v databázi Scopus
2-s2.0-85029484418