Chronobiological perspectives on myocardial electrophysiological parameters under three types of general anaesthesia in a rat model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1901MHN" target="_blank" >RIV/61988987:17110/17:A1901MHN - isvavai.cz</a>

Výsledek na webu

<a href="http://www.tandfonline.com/doi/full/10.1080/09291016.2016.1263003" target="_blank" >http://www.tandfonline.com/doi/full/10.1080/09291016.2016.1263003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09291016.2016.1263003" target="_blank" >10.1080/09291016.2016.1263003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chronobiological perspectives on myocardial electrophysiological parameters under three types of general anaesthesia in a rat model

Popis výsledku v původním jazyce

The specific aim of the present study, with respect to dependence on the light?dark (LD) cycle under in vivo conditions in spontaneously breathing rats was to review initial state in electrophysiological parameters that may predict the development of heart rhythm disorders in pentobarbital (40 mg/kg), ketamine?xylazine (100 + 15 mg/kg) and zoletil (30 mg/kg) anaesthetized animals. The study was performed using female Wistar rats that were adaptated to an LD cycle (12 h:12 h). Heart rate, PQ and QT intervals were evaluated for their dependence on the LD cycle. The longest PQ interval duration is under zoletil anaesthesia in the light period and the longest QT interval duration is under ketamine-xylazine anaesthesia in both light periods. We concluded that the most significant predisposition toward the development of ventricular arrhythmias originating from disorders of impulse production and conduction occurred under zoletil anaesthesia in the light period; those resulting from disorders in the dispersion of refractory periods occurred under ketamine-xylazine anaesthesia in both the light periods.

Název v anglickém jazyce

Chronobiological perspectives on myocardial electrophysiological parameters under three types of general anaesthesia in a rat model

Popis výsledku anglicky

The specific aim of the present study, with respect to dependence on the light?dark (LD) cycle under in vivo conditions in spontaneously breathing rats was to review initial state in electrophysiological parameters that may predict the development of heart rhythm disorders in pentobarbital (40 mg/kg), ketamine?xylazine (100 + 15 mg/kg) and zoletil (30 mg/kg) anaesthetized animals. The study was performed using female Wistar rats that were adaptated to an LD cycle (12 h:12 h). Heart rate, PQ and QT intervals were evaluated for their dependence on the LD cycle. The longest PQ interval duration is under zoletil anaesthesia in the light period and the longest QT interval duration is under ketamine-xylazine anaesthesia in both light periods. We concluded that the most significant predisposition toward the development of ventricular arrhythmias originating from disorders of impulse production and conduction occurred under zoletil anaesthesia in the light period; those resulting from disorders in the dispersion of refractory periods occurred under ketamine-xylazine anaesthesia in both the light periods.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological rhythm research

ISSN

1744-4179

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

344-351

Kód UT WoS článku

000399474500002

EID výsledku v databázi Scopus

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