Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA1901W58" target="_blank" >RIV/61988987:17110/18:A1901W58 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/18:10380677 RIV/00179906:_____/18:10380677 RIV/00843989:_____/18:E0107028

Výsledek na webu

<a href="http://dx.doi.org/10.1111/bjh.15092" target="_blank" >http://dx.doi.org/10.1111/bjh.15092</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bjh.15092" target="_blank" >10.1111/bjh.15092</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients

Popis výsledku v původním jazyce

We report a multicentre retrospective study that analysed clinical characteristics and outcomes in 117 patients with primary plasma cell leukaemia (pPCL) treated at the participating institutions between January 2006 and December 2016. The median age at the time of pPCL diagnosis was 61years. Ninety-eight patients were treated with novel agents, with an overall response rate of 78%. Fifty-five patients (64%) patients underwent upfront autologous stem cell transplantation (ASCT). The median follow-up time was 50months (95% confidence interval [CI] 33; 76), with a median overall survival (OS) for the entire group of 23 months (95% CI 15; 34). The median OS time in patients who underwent upfront ASCT was 35 months (95% CI 24.3; 46) as compared to 13 months (95% CI 6.3; 35.8) in patients who did not receive ASCT (P=0.001). Multivariate analyses identified age >= 60years, platelet count &lt;= 100x10(9)/l and peripheral blood plasma cell count &gt;= 20x10(9)/l as independent predictors of worse survival. The median OS in patients with 0, 1 or 2-3 of these risk factors was 46, 27 and 12months, respectively (P&lt;0.001). Our findings support the use of novel agents and ASCT as frontline treatment in patients with pPCL. The constructed prognostic score should be independently validated.

Název v anglickém jazyce

Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients

Popis výsledku anglicky

We report a multicentre retrospective study that analysed clinical characteristics and outcomes in 117 patients with primary plasma cell leukaemia (pPCL) treated at the participating institutions between January 2006 and December 2016. The median age at the time of pPCL diagnosis was 61years. Ninety-eight patients were treated with novel agents, with an overall response rate of 78%. Fifty-five patients (64%) patients underwent upfront autologous stem cell transplantation (ASCT). The median follow-up time was 50months (95% confidence interval [CI] 33; 76), with a median overall survival (OS) for the entire group of 23 months (95% CI 15; 34). The median OS time in patients who underwent upfront ASCT was 35 months (95% CI 24.3; 46) as compared to 13 months (95% CI 6.3; 35.8) in patients who did not receive ASCT (P=0.001). Multivariate analyses identified age >= 60years, platelet count &lt;= 100x10(9)/l and peripheral blood plasma cell count &gt;= 20x10(9)/l as independent predictors of worse survival. The median OS in patients with 0, 1 or 2-3 of these risk factors was 46, 27 and 12months, respectively (P&lt;0.001). Our findings support the use of novel agents and ASCT as frontline treatment in patients with pPCL. The constructed prognostic score should be independently validated.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BRITISH JOURNAL OF HAEMATOLOGY

ISSN

0007-1048

e-ISSN

1365-2141

Svazek periodika

180

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

831-839

Kód UT WoS článku

000426607200008

EID výsledku v databázi Scopus

2-s2.0-85042936275