Diagnostic value of serum galactomannan, (1,3)-?- d- glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F18%3AA1901Z0K" target="_blank" >RIV/61988987:17110/18:A1901Z0K - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/18:73590269 RIV/71009396:_____/18:N0000002

Výsledek na webu

<a href="https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=10&SID=C62ghN1njNdw8cjli2R&page=1&doc=1" target="_blank" >https://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=10&SID=C62ghN1njNdw8cjli2R&page=1&doc=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/myc.12765" target="_blank" >10.1111/myc.12765</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic value of serum galactomannan, (1,3)-?- d- glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients

Popis výsledku v původním jazyce

Detection of serum galactomannan (GM) and (1,3)-?-d-glucan(BG) is considered usefulfor non-culturediagnosis of invasive pulmonary aspergillosis (IPA) in neutropenicpatients. Only few studies evaluated these seromarkers in non-neutropenicpatientssuspected of having IPA. The aim of this study was to evaluate both tests togetherwith the Aspergillus fumigatus-specificserum IgG and IgA (IgAG) test for serologicalIPA diagnosis in non-neutropenicpatients. Sera from 87 patients suspected of havingIPA were retrospectively analysed. Patients were categorised into groups of provenIPA (n = 10), putative IPA (n = 31) and non-IPAcolonisation (n = 46). When the GM, BGand IgAG assays were used for patients included in the study, the sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 48.8%/91.3%/83.3%/66.7%, 82.9%/73.9%/73.9%/82.9% and 75.6%/95.7%/93.9%/81.5%,respectively. Thus, the highest specificity and PPV were confirmed for the IgAG assay

Název v anglickém jazyce

Diagnostic value of serum galactomannan, (1,3)-?- d- glucan, and Aspergillus fumigatus-specific IgA and IgG assays for invasive pulmonary aspergillosis in non-neutropenic patients

Popis výsledku anglicky

Detection of serum galactomannan (GM) and (1,3)-?-d-glucan(BG) is considered usefulfor non-culturediagnosis of invasive pulmonary aspergillosis (IPA) in neutropenicpatients. Only few studies evaluated these seromarkers in non-neutropenicpatientssuspected of having IPA. The aim of this study was to evaluate both tests togetherwith the Aspergillus fumigatus-specificserum IgG and IgA (IgAG) test for serologicalIPA diagnosis in non-neutropenicpatients. Sera from 87 patients suspected of havingIPA were retrospectively analysed. Patients were categorised into groups of provenIPA (n = 10), putative IPA (n = 31) and non-IPAcolonisation (n = 46). When the GM, BGand IgAG assays were used for patients included in the study, the sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 48.8%/91.3%/83.3%/66.7%, 82.9%/73.9%/73.9%/82.9% and 75.6%/95.7%/93.9%/81.5%,respectively. Thus, the highest specificity and PPV were confirmed for the IgAG assay

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MYCOSES

ISSN

0933-7407

e-ISSN

1439-0507

Svazek periodika

61

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

576-586

Kód UT WoS článku

000439832600007

EID výsledku v databázi Scopus

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