Air pollution and molecular changes in age-related diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA2102628" target="_blank" >RIV/61988987:17110/20:A2102628 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/09603123.2020.1797643#aHR0cHM6Ly93d3cudGFuZGZvbmxpbmUuY29tL2RvaS9wZGYvMTAuMTA4MC8wOTYwMzEyMy4yMDIwLjE3OTc2NDM/bmVlZEFjY2Vzcz10cnVlQEBAMA==" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/09603123.2020.1797643#aHR0cHM6Ly93d3cudGFuZGZvbmxpbmUuY29tL2RvaS9wZGYvMTAuMTA4MC8wOTYwMzEyMy4yMDIwLjE3OTc2NDM/bmVlZEFjY2Vzcz10cnVlQEBAMA==</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09603123.2020.1797643" target="_blank" >10.1080/09603123.2020.1797643</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Air pollution and molecular changes in age-related diseases

Popis výsledku v původním jazyce

Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.

Název v anglickém jazyce

Air pollution and molecular changes in age-related diseases

Popis výsledku anglicky

Assessment of the impact that air contaminants have on health is difficult as this is a complex mixture of substances that varies depending on the time and place. There are many studies on the association between air pollution and increased morbidity and mortality. Before the effect of polluted air is manifested at the level of the organs, an impact can be observed at the molecular level. These include some new biomarkers, like a shortening of the mean telomere length in DNA, dysregulation of gene expression caused by microRNA levels or a variation in the copy number of mitochondrial DNA. These changes may predispose individuals to premature development of age-related diseases and consequently to shortening of life. The common attribute, shared by changes at the molecular level and the development of diseases, is the presence of oxidative stress.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

<a href="/cs/project/EF16_019%2F0000798" target="_blank" >EF16_019/0000798: Healthy Aging in Industrial Environment HAIE</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH

ISSN

0960-3123

e-ISSN

1369-1619

Svazek periodika

—

Číslo periodika v rámci svazku

JUL 2020

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

20

Strana od-do

—

Kód UT WoS článku

000553370700001

EID výsledku v databázi Scopus

2-s2.0-85088820661