Chronobiological study of sex differences in the internal environment in zoletil-anaesthetized rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F20%3AA21028BS" target="_blank" >RIV/61988987:17110/20:A21028BS - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/pdf/10.1080/09291016.2018.1564577?needAccess=true" target="_blank" >https://www.tandfonline.com/doi/pdf/10.1080/09291016.2018.1564577?needAccess=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/09291016.2018.1564577" target="_blank" >10.1080/09291016.2018.1564577</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chronobiological study of sex differences in the internal environment in zoletil-anaesthetized rats

Popis výsledku v původním jazyce

Although it is generally assumed that females are not significantly more variable than males, there are studies that have demonstrated that differences may be quite large. The aim of the presentin vivostudy was to determine the effect of general anaesthesia on the status of acid-base balance in spontaneously breathing rats of both sexes in dependence on the light-dark cycle. The experiments were performed using zoletil-anaesthetized (30mg/kg [intraperitoneal], Virbac, France) female and male Wistar rats, after a four-week adaptation to a light-dark cycle (12 h:12 h). The animals were divided into four experimental groups according to sex and light period (n = 20). The results demonstrated sex differences in acid-base balance, as well as sex-related differences between the light and dark period in zoletil-anaesthetized rats. Both females and males exhibited the same tendency toward changes in the status of acid-base balance in both light periods. The most unfavourable status in the internal environment was exhibited in males during the light period (the lowest pH, the most pronounced hypoxia and hypercapnia), but with the maintenance of light-dark differences. The light-dark differences in paO(2)and paCO(2)were eliminated in females, not in males. The optimal status of acid-base balance occurred during the dark period in males.

Název v anglickém jazyce

Chronobiological study of sex differences in the internal environment in zoletil-anaesthetized rats

Popis výsledku anglicky

Although it is generally assumed that females are not significantly more variable than males, there are studies that have demonstrated that differences may be quite large. The aim of the presentin vivostudy was to determine the effect of general anaesthesia on the status of acid-base balance in spontaneously breathing rats of both sexes in dependence on the light-dark cycle. The experiments were performed using zoletil-anaesthetized (30mg/kg [intraperitoneal], Virbac, France) female and male Wistar rats, after a four-week adaptation to a light-dark cycle (12 h:12 h). The animals were divided into four experimental groups according to sex and light period (n = 20). The results demonstrated sex differences in acid-base balance, as well as sex-related differences between the light and dark period in zoletil-anaesthetized rats. Both females and males exhibited the same tendency toward changes in the status of acid-base balance in both light periods. The most unfavourable status in the internal environment was exhibited in males during the light period (the lowest pH, the most pronounced hypoxia and hypercapnia), but with the maintenance of light-dark differences. The light-dark differences in paO(2)and paCO(2)were eliminated in females, not in males. The optimal status of acid-base balance occurred during the dark period in males.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30500 - Other medical sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOL RHYTHM RES

ISSN

0929-1016

e-ISSN

—

Svazek periodika

51

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

770-779

Kód UT WoS článku

000547524200011

EID výsledku v databázi Scopus

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