Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA22029R0" target="_blank" >RIV/61988987:17110/21:A22029R0 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/21:E0108970

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.15284" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.15284</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jth.15284" target="_blank" >10.1111/jth.15284</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis

Popis výsledku v původním jazyce

Background The outcomes of deep vein thrombosis (DVT) in children with May-Thurner Syndrome (MTS) remain unclear. Objectives This systematic review and patient-level meta-analysis aims to describe the outcomes of children with MTS presenting with DVT. Methods A systematic review of the published literature was performed. Data related to patients <18 years diagnosed with MTS and DVT was extracted. Risk of bias was assessed using the Murad criteria. Outcomes included vessel patency post-treatment, DVT recurrence, and post-thrombotic syndrome (PTS). Predictive and explanatory models were developed for these outcomes. Results In total, 109 cases were identified (age range 4-17 years; 77 females) in 28 studies; 75% of patients had >= 1 additional risk factor for DVT. PTS was seen in 61% of patients, DVT recurrence in 38%, and complete vessel patency post-treatment in 65%. The models developed to predict and explain PTS performed poorly overall. Recurrent thrombosis (adjusted for age and patency) predicted PTS (odds ratio [OR] 3.36, 95% confidence interval [CI] 1.28-8.82). DVT management strategies (adjusted for age and DVT characteristics) predicted vessel patency (OR 2.10, 95% CI 1.43-3.08). Lack of complete vessel patency (adjusted for age and thrombophilia) predicted recurrent DVT (OR 2.70, 95% CI 1.09-6.67). Sensitivity analyses showed the same direction of effects for all outcomes. Conclusions PTS and DVT recurrence occur frequently in pediatric MTS. PTS prediction is complex and it was not possible to identify early predictors to guide clinical practice. Use of imaging-guided therapy and thrombus burden predicted venous patency, and lack of patency predicted DVT recurrence.

Název v anglickém jazyce

Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis

Popis výsledku anglicky

Background The outcomes of deep vein thrombosis (DVT) in children with May-Thurner Syndrome (MTS) remain unclear. Objectives This systematic review and patient-level meta-analysis aims to describe the outcomes of children with MTS presenting with DVT. Methods A systematic review of the published literature was performed. Data related to patients <18 years diagnosed with MTS and DVT was extracted. Risk of bias was assessed using the Murad criteria. Outcomes included vessel patency post-treatment, DVT recurrence, and post-thrombotic syndrome (PTS). Predictive and explanatory models were developed for these outcomes. Results In total, 109 cases were identified (age range 4-17 years; 77 females) in 28 studies; 75% of patients had >= 1 additional risk factor for DVT. PTS was seen in 61% of patients, DVT recurrence in 38%, and complete vessel patency post-treatment in 65%. The models developed to predict and explain PTS performed poorly overall. Recurrent thrombosis (adjusted for age and patency) predicted PTS (odds ratio [OR] 3.36, 95% confidence interval [CI] 1.28-8.82). DVT management strategies (adjusted for age and DVT characteristics) predicted vessel patency (OR 2.10, 95% CI 1.43-3.08). Lack of complete vessel patency (adjusted for age and thrombophilia) predicted recurrent DVT (OR 2.70, 95% CI 1.09-6.67). Sensitivity analyses showed the same direction of effects for all outcomes. Conclusions PTS and DVT recurrence occur frequently in pediatric MTS. PTS prediction is complex and it was not possible to identify early predictors to guide clinical practice. Use of imaging-guided therapy and thrombus burden predicted venous patency, and lack of patency predicted DVT recurrence.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Thrombosis and Haemostasis

ISSN

1538-7933

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1283-1293

Kód UT WoS článku

000635769700001

EID výsledku v databázi Scopus

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