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Early Vascular Aging in Children With Type 1 Diabetes and Ambulatory Normotension

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F21%3AA2202DFH" target="_blank" >RIV/61988987:17110/21:A2202DFH - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064203:_____/21:10435973 RIV/00216208:11130/21:10435973

  • Výsledek na webu

    <a href="https://www.webofscience.com/wos/woscc/full-record/WOS:000738877900001" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:000738877900001</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fped.2021.764004" target="_blank" >10.3389/fped.2021.764004</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Early Vascular Aging in Children With Type 1 Diabetes and Ambulatory Normotension

  • Popis výsledku v původním jazyce

    Background: Preliminary data suggest that target organ damage (TOD) and early vascular aging (EVA) may occur in children with normal blood pressure (BP).Objectives: To analyze TOD and EVA in normotensive (BP <95th percentile on ambulatory BP monitoring) type 1 diabetes children (T1D) in comparison to healthy controls (C).Subjects: 25 T1D aged 13.9 +/- 2.6 years and 22 C aged 14.0 +/- 3.4 years.Methods: We analyzed age- and height-related pulse wave velocity (PWV) Z-scores and expected PWV based on age, height, and mean arterial pressure (MAP). Expected vascular age based on measured PWV was calculated from pooled pediatric and adult PWV norms. Left ventricular mass index (LVMI), estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR) were obtained as markers of TOD.Results: T1D and C groups did not differ in anthropometry, ambulatory, LVMI, and ACR. However, median age- and height-related PWV Z-scores were higher in T1D compared to C (1.08 vs. 0.57, p = 0.006; 0.78 vs. 0.36, p = 0.02, respectively). Mean (+/- SD) difference between measured and expected PWV was 0.58 +/- 0.57 in T1D vs. 0.22 +/- 0.59 in C, p = 0.02. The mean (+/- SD) difference between chronological and expected vascular age was 7.53 +/- 7.74 years in T1D vs. 2.78 +/- 7.01 years in C, p = 0.04.Conclusion: Increased arterial stiffness and increased intraindividual differences between expected and measured PWV as well as between chronological and expected vascular age indicate that EVA may develop in T1D children even at normal ambulatory BP levels.

  • Název v anglickém jazyce

    Early Vascular Aging in Children With Type 1 Diabetes and Ambulatory Normotension

  • Popis výsledku anglicky

    Background: Preliminary data suggest that target organ damage (TOD) and early vascular aging (EVA) may occur in children with normal blood pressure (BP).Objectives: To analyze TOD and EVA in normotensive (BP <95th percentile on ambulatory BP monitoring) type 1 diabetes children (T1D) in comparison to healthy controls (C).Subjects: 25 T1D aged 13.9 +/- 2.6 years and 22 C aged 14.0 +/- 3.4 years.Methods: We analyzed age- and height-related pulse wave velocity (PWV) Z-scores and expected PWV based on age, height, and mean arterial pressure (MAP). Expected vascular age based on measured PWV was calculated from pooled pediatric and adult PWV norms. Left ventricular mass index (LVMI), estimated glomerular filtration rate (eGFR), and urinary albumin/creatinine ratio (ACR) were obtained as markers of TOD.Results: T1D and C groups did not differ in anthropometry, ambulatory, LVMI, and ACR. However, median age- and height-related PWV Z-scores were higher in T1D compared to C (1.08 vs. 0.57, p = 0.006; 0.78 vs. 0.36, p = 0.02, respectively). Mean (+/- SD) difference between measured and expected PWV was 0.58 +/- 0.57 in T1D vs. 0.22 +/- 0.59 in C, p = 0.02. The mean (+/- SD) difference between chronological and expected vascular age was 7.53 +/- 7.74 years in T1D vs. 2.78 +/- 7.01 years in C, p = 0.04.Conclusion: Increased arterial stiffness and increased intraindividual differences between expected and measured PWV as well as between chronological and expected vascular age indicate that EVA may develop in T1D children even at normal ambulatory BP levels.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30209 - Paediatrics

Návaznosti výsledku

  • Projekt

  • Návaznosti

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Frontiers in Pediatrics

  • ISSN

    2296-2360

  • e-ISSN

  • Svazek periodika

    9

  • Číslo periodika v rámci svazku

    prosinec 2021

  • Stát vydavatele periodika

    CH - Švýcarská konfederace

  • Počet stran výsledku

    10

  • Strana od-do

  • Kód UT WoS článku

    000738877900001

  • EID výsledku v databázi Scopus