HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1801TW9" target="_blank" >RIV/61988987:17110/17:A1801TW9 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10373808 RIV/00843989:_____/17:E0106327 RIV/00064203:_____/17:10373808

Výsledek na webu

<a href="http://dx.doi.org/10.1111/pedi.12385" target="_blank" >http://dx.doi.org/10.1111/pedi.12385</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pedi.12385" target="_blank" >10.1111/pedi.12385</a>

Jazyk výsledku

angličtina

Název v původním jazyce

HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes

Popis výsledku v původním jazyce

Obermannova B, Petruzelkova L, Sulakova T, Sumnik Z. HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes. Pediatric Diabetes 2017: 18: 304-310.Background: The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have been performed in children with T1D.Objective: To explore the risk factors associated with AS in adolescents with suboptimally controlled T1D.Patients and methods: Seventy-seven adolescents with T1D were included (39 girls, 38 boys) in this study. The adolescents had a median age of 16 yr (IQR 14-17), median duration of T1D was 9 yr (IQR 6-16), and HbA1c 71 mmol/mol (median, IQR 62-81). PWV was measured as the carotid-femoral pulse transmission time and converted into standard deviation scores (SDS) (adjusted for gender and age) using normative values for children. The risk factors assessed were HbA1c, T1D duration, treatment modality, serum lipids, and blood pressure (BP) measured via ambulatory blood pressure monitoring (ABPM).Results: The PWV did not differ from the reference data (median PWV was 5.1m/s, i.e., -0.01 SDS). A significant positive association was observed between PWV-SDS and HbA1c (p=0.001), total cholesterol (p=0.003), LDL-cholesterol (p=0.003), but not T1D duration (p=0.78) according to the univariate analyses. In the multivariate model, the only significant variable that remained positively associated with PWV-SDS was HbA1c (p=0.03).Conclusions: Most adolescents with suboptimally controlled T1D have normal mean PWV compared to a healthy reference population. Chronic hyperglycemia, not T1D duration, is the main predictor of AS in adolescents.

Název v anglickém jazyce

HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes

Popis výsledku anglicky

Obermannova B, Petruzelkova L, Sulakova T, Sumnik Z. HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes. Pediatric Diabetes 2017: 18: 304-310.Background: The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have been performed in children with T1D.Objective: To explore the risk factors associated with AS in adolescents with suboptimally controlled T1D.Patients and methods: Seventy-seven adolescents with T1D were included (39 girls, 38 boys) in this study. The adolescents had a median age of 16 yr (IQR 14-17), median duration of T1D was 9 yr (IQR 6-16), and HbA1c 71 mmol/mol (median, IQR 62-81). PWV was measured as the carotid-femoral pulse transmission time and converted into standard deviation scores (SDS) (adjusted for gender and age) using normative values for children. The risk factors assessed were HbA1c, T1D duration, treatment modality, serum lipids, and blood pressure (BP) measured via ambulatory blood pressure monitoring (ABPM).Results: The PWV did not differ from the reference data (median PWV was 5.1m/s, i.e., -0.01 SDS). A significant positive association was observed between PWV-SDS and HbA1c (p=0.001), total cholesterol (p=0.003), LDL-cholesterol (p=0.003), but not T1D duration (p=0.78) according to the univariate analyses. In the multivariate model, the only significant variable that remained positively associated with PWV-SDS was HbA1c (p=0.03).Conclusions: Most adolescents with suboptimally controlled T1D have normal mean PWV compared to a healthy reference population. Chronic hyperglycemia, not T1D duration, is the main predictor of AS in adolescents.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NT14335" target="_blank" >NT14335: Tuhost cév u dětí s diabetem mellitem 1.typu - vztah rychlosti pulzní vlny (PWV) a indexu ambulatorní arteriální tuhosti (AASI)</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PEDIATRIC DIABETES

ISSN

1399-543X

e-ISSN

1399-5448

Svazek periodika

6/2017

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

304-310

Kód UT WoS článku

000402892400008

EID výsledku v databázi Scopus

2-s2.0-84963800565