LGI1 encephalitis in childhood

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F23%3AA2402NEH" target="_blank" >RIV/61988987:17110/23:A2402NEH - isvavai.cz</a>

Výsledek na webu

<a href="https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2023-3-9/lgi1-encephalitis-in-childhood-134908?hl=cs" target="_blank" >https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2023-3-9/lgi1-encephalitis-in-childhood-134908?hl=cs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2023208" target="_blank" >10.48095/cccsnn2023208</a>

Jazyk výsledku

angličtina

Název v původním jazyce

LGI1 encephalitis in childhood

Popis výsledku v původním jazyce

We present a case of a pediatric patient who developed autoimmune encephalitis with anti-LGI1 (leucine-rich glioma-inactivated 1) antibody positivity. She was a previously healthy 4-year-old girl admitted to the pediatric intensive care unit for cumulative left-sided predominant faciobrachial dystonic seizures (FBDS). The development of the difficulties was preceded by signs of febrile viral illness. Brain CT, lumbar puncture (LP) and neurological findings were negative. Meningeal syndrome and signs of intracranial hypertension were not expressed. The patient was treated with levetiracetam with beneficial effect. After 2 days, a recurrence of left-sided FBDS occurred. Midazolam and valproate were administered up to the maximum therapeutic dose, and FBDS continued to recur once every 1-2 h. After adding topiramate, the seizures resolved. A psychoorganic syndrome developed, with a predominance of an excitatory component, deterioration of cognitive functions, especially memory, heteroaggression, automatization, hyperphagia, use of vulgarisms, and sleep biorhythm was disturbed. EEG showed encephalopathic recordings. MRI of the brain was negative. Psychological examination confirmed cognitive deterioration by approximately 1.5 years compared to calendar age. Basic oncological screening excluded paraneoplastic process. Re-examination of the lysate showed positivity of anti-LGI1 antibodies.

Název v anglickém jazyce

LGI1 encephalitis in childhood

Popis výsledku anglicky

We present a case of a pediatric patient who developed autoimmune encephalitis with anti-LGI1 (leucine-rich glioma-inactivated 1) antibody positivity. She was a previously healthy 4-year-old girl admitted to the pediatric intensive care unit for cumulative left-sided predominant faciobrachial dystonic seizures (FBDS). The development of the difficulties was preceded by signs of febrile viral illness. Brain CT, lumbar puncture (LP) and neurological findings were negative. Meningeal syndrome and signs of intracranial hypertension were not expressed. The patient was treated with levetiracetam with beneficial effect. After 2 days, a recurrence of left-sided FBDS occurred. Midazolam and valproate were administered up to the maximum therapeutic dose, and FBDS continued to recur once every 1-2 h. After adding topiramate, the seizures resolved. A psychoorganic syndrome developed, with a predominance of an excitatory component, deterioration of cognitive functions, especially memory, heteroaggression, automatization, hyperphagia, use of vulgarisms, and sleep biorhythm was disturbed. EEG showed encephalopathic recordings. MRI of the brain was negative. Psychological examination confirmed cognitive deterioration by approximately 1.5 years compared to calendar age. Basic oncological screening excluded paraneoplastic process. Re-examination of the lysate showed positivity of anti-LGI1 antibodies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE

ISSN

1210-7859

e-ISSN

—

Svazek periodika

—

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

208-210

Kód UT WoS článku

001044269700001

EID výsledku v databázi Scopus

2-s2.0-85166397813