Pseudonormokalemia case report - What does it mean to have normal blood potassium?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F24%3AA25038Z5" target="_blank" >RIV/61988987:17110/24:A25038Z5 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.biochemia-medica.com/en/journal/34/2/10.11613/BM.2024.021002" target="_blank" >https://www.biochemia-medica.com/en/journal/34/2/10.11613/BM.2024.021002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.11613/bm.2024.021002" target="_blank" >10.11613/bm.2024.021002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pseudonormokalemia case report - What does it mean to have normal blood potassium?

Popis výsledku v původním jazyce

Graphical abstractHighlights• Pseudonormokalemia may mean thrombocytosis, serum potassium concentration within reference ranges, and low plasma potassium concentration• The best way to eliminate both pseudohyperkalemia and pseudonormokalemia phenomenon is to completely change towards heparin-plasma as the standard material• Interpretative comments in patients with thrombocytosis over 500x109/L recommending plasma potassium measurement are helpfulThis case report describes a case of pseudonormokalemia, true hypokalemia. Often, only laboratory values outside the normal range gain attention and false normal results are at risk of not being noticed. However, a disease state may be masked by another pathological process. Here, a 50-year old male was admitted to the Department of Internal Medicine due to sepsis from a dental infection. Initially, serum potassium measurement revealed a normal value of 4 mmol/L (reference interval 3.8-5.1 mmol/L). Thrombocyte number was above 500x109/L. Due to our policy to recommend a repeated measurement of potassium in whole blood or heparin plasma if a patient has thrombocytosis, pseudonormokalemia was identified because the heparin plasma potassium value was only 2.9 mmol/L (reference interval 3.5-4.8 mmol/L). The physiological difference between serum and plasma concentration is no more than 0.3 mmol/L. In this case, potassium concentration were falsely elevated in the serum sample, probably caused by the high number of platelets releasing potassium during clotting. Interpretative comments in patients with thrombocytosis over 500x109/L recommending plasma potassium measurement are helpful. The best way to eliminate pseudohyperkalemia and pseudonormokalemia phenomena caused by thrombocytosis is to completely change towards heparin plasma as the standard material.

Název v anglickém jazyce

Pseudonormokalemia case report - What does it mean to have normal blood potassium?

Popis výsledku anglicky

Graphical abstractHighlights• Pseudonormokalemia may mean thrombocytosis, serum potassium concentration within reference ranges, and low plasma potassium concentration• The best way to eliminate both pseudohyperkalemia and pseudonormokalemia phenomenon is to completely change towards heparin-plasma as the standard material• Interpretative comments in patients with thrombocytosis over 500x109/L recommending plasma potassium measurement are helpfulThis case report describes a case of pseudonormokalemia, true hypokalemia. Often, only laboratory values outside the normal range gain attention and false normal results are at risk of not being noticed. However, a disease state may be masked by another pathological process. Here, a 50-year old male was admitted to the Department of Internal Medicine due to sepsis from a dental infection. Initially, serum potassium measurement revealed a normal value of 4 mmol/L (reference interval 3.8-5.1 mmol/L). Thrombocyte number was above 500x109/L. Due to our policy to recommend a repeated measurement of potassium in whole blood or heparin plasma if a patient has thrombocytosis, pseudonormokalemia was identified because the heparin plasma potassium value was only 2.9 mmol/L (reference interval 3.5-4.8 mmol/L). The physiological difference between serum and plasma concentration is no more than 0.3 mmol/L. In this case, potassium concentration were falsely elevated in the serum sample, probably caused by the high number of platelets releasing potassium during clotting. Interpretative comments in patients with thrombocytosis over 500x109/L recommending plasma potassium measurement are helpful. The best way to eliminate pseudohyperkalemia and pseudonormokalemia phenomena caused by thrombocytosis is to completely change towards heparin plasma as the standard material.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOCHEMIA MEDICA

ISSN

1330-0962

e-ISSN

1846-7482

Svazek periodika

—

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

4

Strana od-do

362-365

Kód UT WoS článku

001254069100013

EID výsledku v databázi Scopus

2-s2.0-85196451648