Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F25%3AA2603AU1" target="_blank" >RIV/61988987:17110/25:A2603AU1 - isvavai.cz</a>

Výsledek na webu

<a href="https://linkinghub.elsevier.com/retrieve/pii/S2352906725000594" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S2352906725000594</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcha.2025.101656" target="_blank" >10.1016/j.ijcha.2025.101656</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review

Popis výsledku v původním jazyce

Beyond the stenosis degree, the carotid plaque morphology assessed by computed tomography may improve the stroke risk stratification and is recommended to be considered before interventional treatment according to current guidelines. This study aimed to systematically review the accuracy of computed tomography (CT) to detect carotid plaque characteristics compared to histology in patients with symptomatic and asymptomatic carotid plaques. We registered the protocol in PROSPERO and searched Medline Ovid, Embase.com, Cochrane Library, and Web of Science for diagnostic accuracy of CT in specific carotid plaque characteristic imaging compared to histology, without any search limitation up to May 27, 2022. Out of 8,168 studies, 20 studies that evaluated seven specific plaque characteristics were included in our systematic review. The best diagnostic performance was found for the detection of ulceration (sensitivity range 39.4–100% [mean 79.6%], specificity range 74–100% [mean 93.6%]), followed by calcification (72.7–100% [88.1%], 35.7–100% [80.1%]), lipid-rich necrotic core (63.2–95.6% [81.1%], 60–100% [80.1%]), and intraplaque hemorrhage (61.5–100% [86%], 20–99.5% [67.8%]). Only a few studies evaluated specifically vulnerable, mixed, and fibrous plaque. Diagnostic studies with larger sample sizes are needed, using novel available CT techniques that enable increasing diagnostic performance and decreasing radiation and amount of contrast agent. CT allows for highly accurate detection of carotid plaque features, particularly ulceration and calcification. These results underline the role of routine CT examinations to assess not only stenosis degree but also plaque morphology and individual patient stroke risk to better guide management. Registration: PROSPERO ID CRD42022329690 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=329690)

Název v anglickém jazyce

Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review

Popis výsledku anglicky

Beyond the stenosis degree, the carotid plaque morphology assessed by computed tomography may improve the stroke risk stratification and is recommended to be considered before interventional treatment according to current guidelines. This study aimed to systematically review the accuracy of computed tomography (CT) to detect carotid plaque characteristics compared to histology in patients with symptomatic and asymptomatic carotid plaques. We registered the protocol in PROSPERO and searched Medline Ovid, Embase.com, Cochrane Library, and Web of Science for diagnostic accuracy of CT in specific carotid plaque characteristic imaging compared to histology, without any search limitation up to May 27, 2022. Out of 8,168 studies, 20 studies that evaluated seven specific plaque characteristics were included in our systematic review. The best diagnostic performance was found for the detection of ulceration (sensitivity range 39.4–100% [mean 79.6%], specificity range 74–100% [mean 93.6%]), followed by calcification (72.7–100% [88.1%], 35.7–100% [80.1%]), lipid-rich necrotic core (63.2–95.6% [81.1%], 60–100% [80.1%]), and intraplaque hemorrhage (61.5–100% [86%], 20–99.5% [67.8%]). Only a few studies evaluated specifically vulnerable, mixed, and fibrous plaque. Diagnostic studies with larger sample sizes are needed, using novel available CT techniques that enable increasing diagnostic performance and decreasing radiation and amount of contrast agent. CT allows for highly accurate detection of carotid plaque features, particularly ulceration and calcification. These results underline the role of routine CT examinations to assess not only stenosis degree but also plaque morphology and individual patient stroke risk to better guide management. Registration: PROSPERO ID CRD42022329690 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=329690)

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IJC Heart & Vasculature

ISSN

2352-9067

e-ISSN

2352-9067

Svazek periodika

—

Číslo periodika v rámci svazku

June 2025

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

001453443200001

EID výsledku v databázi Scopus

2-s2.0-105000238644