Histologically Verified Carotid Plaque Characteristics by Ultrasound: A Diagnostic Accuracy Systematic Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F25%3AA2603DM6" target="_blank" >RIV/61988987:17110/25:A2603DM6 - isvavai.cz</a>

Výsledek na webu

<a href="https://linkinghub.elsevier.com/retrieve/pii/S0301562925002303" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S0301562925002303</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ultrasmedbio.2025.07.001" target="_blank" >10.1016/j.ultrasmedbio.2025.07.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Histologically Verified Carotid Plaque Characteristics by Ultrasound: A Diagnostic Accuracy Systematic Review

Popis výsledku v původním jazyce

Ultrasound (US) has been considered the first-line diagnostic technique for evaluating carotid atherosclerosis, where plaque composition plays a key role in stroke risk. We aimed to analyze the diagnostic accuracy of carotid plaque characteristics using US techniques compared to histology in patients with symptomatic/asymptomatic carotid plaques. After prospective study registration in PROSPERO, we searched Medline Ovid, Embase.com, Cochrane Library, and Web of Science without any search limitation for the diagnostic accuracy of US in detecting carotid plaque features based on histology. From 8168 studies, 63 were included evaluating 13 histologically verified plaque characteristics by 14 different US techniques. Diagnostic accuracies for all plaque characteristics usually varied between 35% and 100% without a trend towards increasing accuracy over the last 40 y but were affected by large heterogeneity. In characteristics with >5 diagnostic accuracy comparisons, the highest diagnostic performance was found for detection of calcification (mean sensitivity 65.7%/mean specificity 84.7%), fibrous tissue (61.2%/84.9%), vulnerable/unstable plaque (76.3%/70.3%), and stable plaque (63.2%/82.7%). However, several advanced techniques investigated showed high diagnostic accuracy, promising interesting diagnostic options for the future. Carotid US allows for widely available and reliable evaluation of atherosclerotic plaque morphology by conventional and advanced techniques. Registration: PROSPERO ID CRD42022329690 (https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=329690).

Název v anglickém jazyce

Histologically Verified Carotid Plaque Characteristics by Ultrasound: A Diagnostic Accuracy Systematic Review

Popis výsledku anglicky

Ultrasound (US) has been considered the first-line diagnostic technique for evaluating carotid atherosclerosis, where plaque composition plays a key role in stroke risk. We aimed to analyze the diagnostic accuracy of carotid plaque characteristics using US techniques compared to histology in patients with symptomatic/asymptomatic carotid plaques. After prospective study registration in PROSPERO, we searched Medline Ovid, Embase.com, Cochrane Library, and Web of Science without any search limitation for the diagnostic accuracy of US in detecting carotid plaque features based on histology. From 8168 studies, 63 were included evaluating 13 histologically verified plaque characteristics by 14 different US techniques. Diagnostic accuracies for all plaque characteristics usually varied between 35% and 100% without a trend towards increasing accuracy over the last 40 y but were affected by large heterogeneity. In characteristics with >5 diagnostic accuracy comparisons, the highest diagnostic performance was found for detection of calcification (mean sensitivity 65.7%/mean specificity 84.7%), fibrous tissue (61.2%/84.9%), vulnerable/unstable plaque (76.3%/70.3%), and stable plaque (63.2%/82.7%). However, several advanced techniques investigated showed high diagnostic accuracy, promising interesting diagnostic options for the future. Carotid US allows for widely available and reliable evaluation of atherosclerotic plaque morphology by conventional and advanced techniques. Registration: PROSPERO ID CRD42022329690 (https://www.crd.york.ac.uk/prospero/display_record.php? RecordID=329690).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ultrasound in Medicine & Biology

ISSN

0301-5629

e-ISSN

1879-291X

Svazek periodika

—

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

1646-1659

Kód UT WoS článku

001562185000001

EID výsledku v databázi Scopus

2-s2.0-105011842818