Catalase in Leishmaniinae: With me or against me?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F17%3AA1801OCS" target="_blank" >RIV/61988987:17310/17:A1801OCS - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/17:00485316 RIV/60076658:12310/17:43895455

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.meegid.2016.06.054" target="_blank" >http://dx.doi.org/10.1016/j.meegid.2016.06.054</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.meegid.2016.06.054" target="_blank" >10.1016/j.meegid.2016.06.054</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Catalase in Leishmaniinae: With me or against me?

Popis výsledku v původním jazyce

The catalase gene is a virtually ubiquitous component of the eukaryotic genomes. It is also present in the monoxenous (i.e. parasitizing solely insects) trypanosomatids of the subfamily Leishmaniinae, which have acquired the enzyme by horizontal gene transfer from a bacterium. However, as shown here, the catalase gene was secondarily lost from the genomes of all Leishmania sequenced so far. Due to the potentially key regulatory role of hydrogen peroxide in the inter-stagial transformation of Leishmania spp., this loss seems to be a necessary prerequisite for the emergence of a complex life cycle of these important human pathogens. Hence, in this group of protists, the advantages of keeping catalase were uniquely outweighed by its disadvantages. (C) 2016 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Catalase in Leishmaniinae: With me or against me?

Popis výsledku anglicky

The catalase gene is a virtually ubiquitous component of the eukaryotic genomes. It is also present in the monoxenous (i.e. parasitizing solely insects) trypanosomatids of the subfamily Leishmaniinae, which have acquired the enzyme by horizontal gene transfer from a bacterium. However, as shown here, the catalase gene was secondarily lost from the genomes of all Leishmania sequenced so far. Due to the potentially key regulatory role of hydrogen peroxide in the inter-stagial transformation of Leishmania spp., this loss seems to be a necessary prerequisite for the emergence of a complex life cycle of these important human pathogens. Hence, in this group of protists, the advantages of keeping catalase were uniquely outweighed by its disadvantages. (C) 2016 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INFECTION GENETICS AND EVOLUTION

ISSN

1567-1348

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

Červen

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

121-127

Kód UT WoS článku

000399514100018

EID výsledku v databázi Scopus

—