Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F20%3AA21027WN" target="_blank" >RIV/61988987:17310/20:A21027WN - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/20:00523977 RIV/62156489:43110/20:43916735 RIV/00216305:26310/20:PU133360

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0888754319305269" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0888754319305269</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ygeno.2019.11.002" target="_blank" >10.1016/j.ygeno.2019.11.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

Popis výsledku v původním jazyce

The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes.

Název v anglickém jazyce

Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

Popis výsledku anglicky

The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

<a href="/cs/project/GA18-15548S" target="_blank" >GA18-15548S: Srovnávací studie DNA interakčních vlastností izoforem nádorového supresoru proteinu p53</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Genomics

ISSN

0888-7543

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1897-1901

Kód UT WoS článku

000514071600093

EID výsledku v databázi Scopus

—