Evolution of Diverse Strategies for Promoter Regulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F21%3AA2202A6I" target="_blank" >RIV/61988987:17310/21:A2202A6I - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/21:00544549

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0168952521000846" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0168952521000846</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tig.2021.04.003" target="_blank" >10.1016/j.tig.2021.04.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evolution of Diverse Strategies for Promoter Regulation

Popis výsledku v původním jazyce

DNA is fundamentally important for all cellular organisms due to its role as a store of hereditary genetic information. The precise and accurate regulation of gene transcription depends primarily on promoters, which vary significantly within and between genomes. Some promoters are rich in specific types of bases, while others have more varied, complex sequence characteristics. However, it is not only base sequence but also epigenetic modifications and altered DNA structure that regulate promoter activity. Significantly, many promoters across all organisms contain sequences that can form intrastrand hairpins (cruciforms) or four-stranded structures (G-quadruplex or i-motif). In this review we integrate recent studies on promoter regulation that highlight the importance of DNA structure in the evolutionary adaptation of promoter sequences.

Název v anglickém jazyce

Evolution of Diverse Strategies for Promoter Regulation

Popis výsledku anglicky

DNA is fundamentally important for all cellular organisms due to its role as a store of hereditary genetic information. The precise and accurate regulation of gene transcription depends primarily on promoters, which vary significantly within and between genomes. Some promoters are rich in specific types of bases, while others have more varied, complex sequence characteristics. However, it is not only base sequence but also epigenetic modifications and altered DNA structure that regulate promoter activity. Significantly, many promoters across all organisms contain sequences that can form intrastrand hairpins (cruciforms) or four-stranded structures (G-quadruplex or i-motif). In this review we integrate recent studies on promoter regulation that highlight the importance of DNA structure in the evolutionary adaptation of promoter sequences.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

<a href="/cs/project/GA18-15548S" target="_blank" >GA18-15548S: Srovnávací studie DNA interakčních vlastností izoforem nádorového supresoru proteinu p53</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trends in Genetics

ISSN

0168-9525

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

730-744

Kód UT WoS článku

000674082400008

EID výsledku v databázi Scopus

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