Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27240%2F15%3A86096523" target="_blank" >RIV/61989100:27240/15:86096523 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/15:43875423 RIV/62690094:18450/15:50003718 RIV/62690094:18470/15:50003718 RIV/00179906:_____/15:10301850

Výsledek na webu

<a href="http://dx.doi.org/10.2174/1573406411666150407154204" target="_blank" >http://dx.doi.org/10.2174/1573406411666150407154204</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1573406411666150407154204" target="_blank" >10.2174/1573406411666150407154204</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE

Popis výsledku v původním jazyce

Oxime K203 seems to be the most promising oxime in case of reactivation of tabun-inhibited acetylcholinesterase (AChE). Although it was originally developed for treatment of tabun intoxications, it is able to reactivate cholinesterases inhibited by othernerve agents. This study is aimed at the evaluation of its potency in vitro against other nerve agents. For this purpose, sarin, tabun, cyclosarin, soman, VX, Russian VX and DFP were selected as members of the nerve agent family to check its universality. At high concentrations (10(-3) M), oxime K203 reached promising reactivation activity. At low concentrations, relevant for human use (10(-5) M), promising reactivation potency was obtained only with tabun. In conclusion, oxime K203 reactivates other nerve agents-inhibited cholinesterases, however its broad-spectrum reactivation is limited at high, for human not attainable, concentrations only.

Název v anglickém jazyce

Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE

Popis výsledku anglicky

Oxime K203 seems to be the most promising oxime in case of reactivation of tabun-inhibited acetylcholinesterase (AChE). Although it was originally developed for treatment of tabun intoxications, it is able to reactivate cholinesterases inhibited by othernerve agents. This study is aimed at the evaluation of its potency in vitro against other nerve agents. For this purpose, sarin, tabun, cyclosarin, soman, VX, Russian VX and DFP were selected as members of the nerve agent family to check its universality. At high concentrations (10(-3) M), oxime K203 reached promising reactivation activity. At low concentrations, relevant for human use (10(-5) M), promising reactivation potency was obtained only with tabun. In conclusion, oxime K203 reactivates other nerve agents-inhibited cholinesterases, however its broad-spectrum reactivation is limited at high, for human not attainable, concentrations only.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicinal Chemistry

ISSN

1573-4064

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

4

Strana od-do

683-686

Kód UT WoS článku

000361825400011

EID výsledku v databázi Scopus

2-s2.0-84947812206