Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27240%2F17%3A10238713" target="_blank" >RIV/61989100:27240/17:10238713 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/17:73582608
Výsledek na webu
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689581/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689581/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/oncotarget.20031" target="_blank" >10.18632/oncotarget.20031</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects
Popis výsledku v původním jazyce
A growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL). The percentage of CD54+ and CD64+ neutrophils as well as CD54 expression on these cells were higher in CLL patients than in age-matched healthy controls. Neutrophils from CLL produced more reactive oxygen species (ROS) compared to controls in both resting and activated conditions. Lipopolysaccharide-induced production of IL-1β and TNF-α as well as reduced TLR2 expression in neutrophils from CLL than in neutrophils from controls suggesting their tolerant state. Finally, phenotypic alterations of neutrophils, particularly elevation of CD64 and CD54 markers, correlated with disease activity and treatment, and low percentage of neutrophils. Taken together, the alterations in percentage and functional characteristics of neutrophils reflect the clinical course of CLL. Our data provide first evidence that neutrophils in CLL are permanently primed and have functional defects. © Manukyan et al.
Název v anglickém jazyce
Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects
Popis výsledku anglicky
A growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL). The percentage of CD54+ and CD64+ neutrophils as well as CD54 expression on these cells were higher in CLL patients than in age-matched healthy controls. Neutrophils from CLL produced more reactive oxygen species (ROS) compared to controls in both resting and activated conditions. Lipopolysaccharide-induced production of IL-1β and TNF-α as well as reduced TLR2 expression in neutrophils from CLL than in neutrophils from controls suggesting their tolerant state. Finally, phenotypic alterations of neutrophils, particularly elevation of CD64 and CD54 markers, correlated with disease activity and treatment, and low percentage of neutrophils. Taken together, the alterations in percentage and functional characteristics of neutrophils reflect the clinical course of CLL. Our data provide first evidence that neutrophils in CLL are permanently primed and have functional defects. © Manukyan et al.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Oncotarget
ISSN
1949-2553
e-ISSN
—
Svazek periodika
8
Číslo periodika v rámci svazku
49
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
13
Strana od-do
84889-84901
Kód UT WoS článku
000413077800036
EID výsledku v databázi Scopus
2-s2.0-85031500691