Stability Study of Cimetidine Nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F16%3A86099190" target="_blank" >RIV/61989100:27640/16:86099190 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989100:27740/16:86099190

Výsledek na webu

<a href="http://dx.doi.org/10.1166/asl.2016.6914" target="_blank" >http://dx.doi.org/10.1166/asl.2016.6914</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1166/asl.2016.6914" target="_blank" >10.1166/asl.2016.6914</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Stability Study of Cimetidine Nanoparticles

Popis výsledku v původním jazyce

This study is focused on a stability investigation of thirty-six samples of cimetidine nanoparticles that were prepared using antisolvent precipitation-solvent evaporation and emulsion solvent evaporation methods. Two types of solvents, two types of surfactants and three types of polymers as stabilizers were chosen. Dynamic light scattering was used for the determination of nanoparticles size. A dark tempered chamber for sample storage and the period of 7 days were chosen as conditions for stability study. Acetone was found to be preferable solvent in terms of stability. Tween 80 and the combination of sodium dodecyl sulfate and macrogol 6000 were the most suitable excipients for stabilization of cimetidine nanoparticles, i.e., no crystallization occurred during storage.

Název v anglickém jazyce

Stability Study of Cimetidine Nanoparticles

Popis výsledku anglicky

This study is focused on a stability investigation of thirty-six samples of cimetidine nanoparticles that were prepared using antisolvent precipitation-solvent evaporation and emulsion solvent evaporation methods. Two types of solvents, two types of surfactants and three types of polymers as stabilizers were chosen. Dynamic light scattering was used for the determination of nanoparticles size. A dark tempered chamber for sample storage and the period of 7 days were chosen as conditions for stability study. Acetone was found to be preferable solvent in terms of stability. Tween 80 and the combination of sodium dodecyl sulfate and macrogol 6000 were the most suitable excipients for stabilization of cimetidine nanoparticles, i.e., no crystallization occurred during storage.

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: Centrum excelence IT4Innovations</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Advanced Science Letters : 4th Biennial Nanomaterials and Nanotechnology International Conference : proceedings : May 18-21, 2015, Ostrava, Czech Republic

ISBN

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ISSN

1936-6612

e-ISSN

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Počet stran výsledku

3

Strana od-do

708-710

Název nakladatele

American Scientific Publishers

Místo vydání

Valencia

Místo konání akce

Ostrava

Datum konání akce

18. 5. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000381233100025