Antimicrobial ciclopiroxolamine/clay nanocomposites

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F18%3A10240007" target="_blank" >RIV/61989100:27640/18:10240007 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2214785318309441" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2214785318309441</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matpr.2018.05.053" target="_blank" >10.1016/j.matpr.2018.05.053</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antimicrobial ciclopiroxolamine/clay nanocomposites

Popis výsledku v původním jazyce

The clay minerals are commonly used materials in pharmaceutical field both as inorganic excipients or active agents. We focused on the development of long-acting antimicrobial formula where clay minerals act as inorganic antimicrobial drug carries. Two series of organoclay nanocomposites with increasing amount of active antifungal drug ciclopiroxolamine were successfully synthesized through the intercalation reaction. In the first case clay mineral vermiculite was used as supporting matrix and secondly clay mineral bentonite was used. The structural characteristics of all prepared samples were studied by XRD and FTIR techniques. Furthermore, the content of organic carbon was determined for nanocomposite samples. Antimicrobial activity of nanocomposites was tested against bacterial strains Staphylococcus aureus and Escherichia coli, and against yeast Candida albicans and it was evaluated by finding minimum inhibitory concentration (MIC). Generally, nanocomposites based on clay mineral bentonite possess better antimicrobial activity.

Název v anglickém jazyce

Antimicrobial ciclopiroxolamine/clay nanocomposites

Popis výsledku anglicky

The clay minerals are commonly used materials in pharmaceutical field both as inorganic excipients or active agents. We focused on the development of long-acting antimicrobial formula where clay minerals act as inorganic antimicrobial drug carries. Two series of organoclay nanocomposites with increasing amount of active antifungal drug ciclopiroxolamine were successfully synthesized through the intercalation reaction. In the first case clay mineral vermiculite was used as supporting matrix and secondly clay mineral bentonite was used. The structural characteristics of all prepared samples were studied by XRD and FTIR techniques. Furthermore, the content of organic carbon was determined for nanocomposite samples. Antimicrobial activity of nanocomposites was tested against bacterial strains Staphylococcus aureus and Escherichia coli, and against yeast Candida albicans and it was evaluated by finding minimum inhibitory concentration (MIC). Generally, nanocomposites based on clay mineral bentonite possess better antimicrobial activity.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Projekt

<a href="/cs/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: Centrum excelence IT4Innovations</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Materials Today: Proceedings. Volume 5, Supplement 1

ISBN

—

ISSN

2214-7853

e-ISSN

2214-7853

Počet stran výsledku

9

Strana od-do

"S20"-"S28"

Název nakladatele

Elsevier

Místo vydání

Amsterdam

Místo konání akce

Ostrava

Datum konání akce

22. 5. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000482182400004