Metronidazole/clay nanocomposites: Synthesis, structure and antibacterial efficacy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F21%3A10246533" target="_blank" >RIV/61989100:27640/21:10246533 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2214785320308476?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2214785320308476?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matpr.2020.02.101" target="_blank" >10.1016/j.matpr.2020.02.101</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metronidazole/clay nanocomposites: Synthesis, structure and antibacterial efficacy

Popis výsledku v původním jazyce

Clays are materials commonly used in the pharmaceutical industry, either as excipients or as active substances. It was observed that when they are administered concurrently, they may interact with drugs reducing their absorption. Such interactions can be used to achieve technological and biopharmaceutical advantages, regarding the control of release. Interactions between clay minerals and drugs may be biopharmaceutically beneficial to improve solubility and/or change drug release profile. This study is focused on the preparation and characterization of organoclay vermiculite and/or bentonite) nanocomposite materials based on imidazole derivative metronidazole, which is antibiotic drug used predominantly for treatment of intestinal and periodontal diseases. The structure of prepared samples was characterized by the X-ray diffractometry (XRD) and infrared spectroscopy (FTIR). Furthermore, the content of organic carbon was determined in the nanocomposite samples by multiphase carbon and hydrogen/ moisture analyzer. Antimicrobial activity of nanocomposites was tested against bacterial strains S. aureus, E. faecalis, P. aeruginosa and E. coli, and it was evaluated by finding minimum inhibitory concentration (MIC). It was found that antibacterial activity depends on pH and also on clay matrix.

Název v anglickém jazyce

Metronidazole/clay nanocomposites: Synthesis, structure and antibacterial efficacy

Popis výsledku anglicky

Clays are materials commonly used in the pharmaceutical industry, either as excipients or as active substances. It was observed that when they are administered concurrently, they may interact with drugs reducing their absorption. Such interactions can be used to achieve technological and biopharmaceutical advantages, regarding the control of release. Interactions between clay minerals and drugs may be biopharmaceutically beneficial to improve solubility and/or change drug release profile. This study is focused on the preparation and characterization of organoclay vermiculite and/or bentonite) nanocomposite materials based on imidazole derivative metronidazole, which is antibiotic drug used predominantly for treatment of intestinal and periodontal diseases. The structure of prepared samples was characterized by the X-ray diffractometry (XRD) and infrared spectroscopy (FTIR). Furthermore, the content of organic carbon was determined in the nanocomposite samples by multiphase carbon and hydrogen/ moisture analyzer. Antimicrobial activity of nanocomposites was tested against bacterial strains S. aureus, E. faecalis, P. aeruginosa and E. coli, and it was evaluated by finding minimum inhibitory concentration (MIC). It was found that antibacterial activity depends on pH and also on clay matrix.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Materials Today: Proceedings. Volume 37, Part 1

ISBN

—

ISSN

2214-7853

e-ISSN

2214-7853

Počet stran výsledku

7

Strana od-do

21-27

Název nakladatele

Elsevier

Místo vydání

Londýn

Místo konání akce

Ostrava

Datum konání akce

13. 5. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000614126700004