Encapsulation of hydrophobic drugs in hyaluronic acid nanofibers: effect of the solution preparation procedure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F21%3A10249602" target="_blank" >RIV/61989100:27640/21:10249602 - isvavai.cz</a>

Výsledek na webu

<a href="https://cnt.vsb.cz/export/sites/cnt/.content/galerie-souboru/Nanomaterials-and-Nanotechnology-in-2021.pdf" target="_blank" >https://cnt.vsb.cz/export/sites/cnt/.content/galerie-souboru/Nanomaterials-and-Nanotechnology-in-2021.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Encapsulation of hydrophobic drugs in hyaluronic acid nanofibers: effect of the solution preparation procedure

Popis výsledku v původním jazyce

Perspective application of nanofibrous mats composed of hydrophilic polymers are the fastdissolving drug delivery systems for immediate release of a wide spectrum of additives, including poorly soluble drugs. For the effective preparation of drug carriers, it is necessary to load additives with high encapsulation efficiency. In our study, we aimed to prepare hyaluronic acid/polyethylenoxide nanofibers with a hydrophobic antiseptic agent (ANT). We have used several approaches of solution preparation to achieve ideally 100 % encapsulation efficiency of ANT. The approaches included dispersing ANT in polymer solution (dispersion), creating an emulsion with the surfactant Tween 60 in water before dissolving the polymers (emulsion), and dissolving all the components in a single solvent system (blend). The morphology of the nanofibers was characterized by SEM, amount of encapsulated ANT was analyzed by HPLC, and the distribution of ANT was mapped by Raman spectroscopy. The best results were obtained by blend electrospinning. The encapsulation efficiency of ANT was over 95 % and ANT was distributed in the nanofiber mat homogeneously. The yield of the electrospinning process was also 3-fold higher than the yield of dispersion and emulsion electrospinning.

Název v anglickém jazyce

Encapsulation of hydrophobic drugs in hyaluronic acid nanofibers: effect of the solution preparation procedure

Popis výsledku anglicky

Perspective application of nanofibrous mats composed of hydrophilic polymers are the fastdissolving drug delivery systems for immediate release of a wide spectrum of additives, including poorly soluble drugs. For the effective preparation of drug carriers, it is necessary to load additives with high encapsulation efficiency. In our study, we aimed to prepare hyaluronic acid/polyethylenoxide nanofibers with a hydrophobic antiseptic agent (ANT). We have used several approaches of solution preparation to achieve ideally 100 % encapsulation efficiency of ANT. The approaches included dispersing ANT in polymer solution (dispersion), creating an emulsion with the surfactant Tween 60 in water before dissolving the polymers (emulsion), and dissolving all the components in a single solvent system (blend). The morphology of the nanofibers was characterized by SEM, amount of encapsulated ANT was analyzed by HPLC, and the distribution of ANT was mapped by Raman spectroscopy. The best results were obtained by blend electrospinning. The encapsulation efficiency of ANT was over 95 % and ANT was distributed in the nanofiber mat homogeneously. The yield of the electrospinning process was also 3-fold higher than the yield of dispersion and emulsion electrospinning.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

21000 - Nano-technology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanomaterials and Nanotechnology in 2021

ISBN

978-80-248-4585-2

Počet stran výsledku

4

Strana od-do

78-81

Počet stran knihy

143

Název nakladatele

VŠB - Technical University of Ostrava

Místo vydání

Ostrava

Kód UT WoS kapitoly

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