Volné plazmatické metanefriny jako skríningový test pro feochromocytom v neselektované populaci pacientů s nízkým pretestovým rizikem

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004443" target="_blank" >RIV/61989592:15110/07:00004443 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Free plasma metanephrines as a screeining test for pheochromocytoma in low-risk patients

Popis výsledku v původním jazyce

Objectives: Detection of free plasma metanephrines seems to be the most exact method for biochemical diagnosis of pheochromocytonoma, but their diagnostic efficacy in the common low-risk clinical settings is debated. Methods: A cross-sectional multicentre study including 1260 subjects assessed the diagnostic efficacy of free plasma metanephrine and normetanephrine in low-risk patients screened for resistant or markedly accelerated hypertension, paroxysmal hypertension, "flushes", and, in a small proportion, for adrenal incidentaloma or genetic predisposition to pheochromocytoma. Results: Pheochromocytoma was identified and verified by histology in 25 subjects (2%), with the diagnosis not confirmed by long-ter, follow-up or use of imaging techniques inthe remaining 1235 individuals. The combined assay of free plasma metanephrines was a highly sensitive (100%) and specific (96,7%) measure, yielding a negative predictive value of 100%. Conclusion: The satisfactory diagnostic efficacy of

Název v anglickém jazyce

Free plasma metanephrines as a screeining test for pheochromocytoma in low-risk patients

Popis výsledku anglicky

Objectives: Detection of free plasma metanephrines seems to be the most exact method for biochemical diagnosis of pheochromocytonoma, but their diagnostic efficacy in the common low-risk clinical settings is debated. Methods: A cross-sectional multicentre study including 1260 subjects assessed the diagnostic efficacy of free plasma metanephrine and normetanephrine in low-risk patients screened for resistant or markedly accelerated hypertension, paroxysmal hypertension, "flushes", and, in a small proportion, for adrenal incidentaloma or genetic predisposition to pheochromocytoma. Results: Pheochromocytoma was identified and verified by histology in 25 subjects (2%), with the diagnosis not confirmed by long-ter, follow-up or use of imaging techniques inthe remaining 1235 individuals. The combined assay of free plasma metanephrines was a highly sensitive (100%) and specific (96,7%) measure, yielding a negative predictive value of 100%. Conclusion: The satisfactory diagnostic efficacy of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hypertension

ISSN

0263-6352

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1427-1431

Kód UT WoS článku

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EID výsledku v databázi Scopus

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