Jednonukleotidové polymorfismy v genech CCL chemokinů u plicní sarkoidózy a systémové sklerózy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006075" target="_blank" >RIV/61989592:15110/08:00006075 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Single Nucleotide Polymorphisms within CCL Chemokine Genes in Pulmonary Sarcoidosis and Systemic Sclerosis

Popis výsledku v původním jazyce

Chemokines (chemotactic cytokines) are small proteins that are secreted extracellularly and chemoattract leukocytes in a specific direction; it is along the gradient of their increasing concentration to the site of the chemokines´origin. A representativemember of CC chemokine family is MCP (monocyte chemoattractant protein) ? 1, also known as CCL2 in the systemic nomenclature, that attracts mainly mononuclear cells to site of inflammation. Other CC chemokine CCL5/RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a potent chemoattractant for both mononuclear cells and eosinophilic granulocytes. Because of their chemotactic activities, the up-regulation of MCP-1 and RANTES is supposed to be involved in pathogenesis of many diseases including pulmonary sarcoidosis and systemic sclerosis (scleroderma). Given a genetic component of both diseases, I postulate hypothesis that some single nucleotide polymorphisms (SNPs) within the genes encoding for MCR-1 and RANTES

Název v anglickém jazyce

Single Nucleotide Polymorphisms within CCL Chemokine Genes in Pulmonary Sarcoidosis and Systemic Sclerosis

Popis výsledku anglicky

Chemokines (chemotactic cytokines) are small proteins that are secreted extracellularly and chemoattract leukocytes in a specific direction; it is along the gradient of their increasing concentration to the site of the chemokines´origin. A representativemember of CC chemokine family is MCP (monocyte chemoattractant protein) ? 1, also known as CCL2 in the systemic nomenclature, that attracts mainly mononuclear cells to site of inflammation. Other CC chemokine CCL5/RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a potent chemoattractant for both mononuclear cells and eosinophilic granulocytes. Because of their chemotactic activities, the up-regulation of MCP-1 and RANTES is supposed to be involved in pathogenesis of many diseases including pulmonary sarcoidosis and systemic sclerosis (scleroderma). Given a genetic component of both diseases, I postulate hypothesis that some single nucleotide polymorphisms (SNPs) within the genes encoding for MCR-1 and RANTES

Druh

O - Ostatní výsledky

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů