Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A33117551" target="_blank" >RIV/61989592:15110/08:33117551 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis

Popis výsledku v původním jazyce

Bone remodeling is a tighitly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, with operate in conjuction with local and systemic factors in a discrete anatomic structuredesignated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influence by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this maylead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have reported the past, including RANKL/RANK/TRAF6, TNF-alpha/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expressions and functional activity of all these Molecules can be affected by variations in their genes. These may explai the differences in severity of bone defec

Název v anglickém jazyce

Bone remodeling, particle disease and individual suspectibility to periprosthetic osteolysis

Popis výsledku anglicky

Bone remodeling is a tighitly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, with operate in conjuction with local and systemic factors in a discrete anatomic structuredesignated a basic multicellular unit (BMU). The microenvironment around total joint arthroplasty is a dynamic and complex milieu influence by the chemical and physical stimuli associated with servicing the prosthesis. A key factor limiting the longevity of the prosthesis is polyethylene wear, which induces particle disease, and this maylead to increased and prolonged activity of BMUs resulting in periprosthetic osteolysis. Several pathways regulating BMU function have reported the past, including RANKL/RANK/TRAF6, TNF-alpha/TNFR/TRAF1, and IL-6/CD126/JAK/STAT. Moreover, the expressions and functional activity of all these Molecules can be affected by variations in their genes. These may explai the differences in severity of bone defec

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FI - Traumatologie a ortopedie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research (print)

ISSN

0862-8408

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

339-349

Kód UT WoS článku

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EID výsledku v databázi Scopus

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