Lipid-Altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolemic patients inadequately controlled with prior statin monotherapy - the IN-CROSS study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009535" target="_blank" >RIV/61989592:15110/09:00009535 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lipid-Altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolemic patients inadequately controlled with prior statin monotherapy - the IN-CROSS study

Popis výsledku v původním jazyce

To evaluate the efficacy of switching from a previous statin monotherapy to ezetimibe/simvastatin (EZE/SIMVA) 10/20 mg vs. rosuvastatin (ROSUVA) 10 mg. In this randomised, double-blind study, 618 patients with documented hypercholesterolaemia (low-density lipoprotein cholesterol /LDL-C/ >=2.59 and <=4.92 mmol/l) and with high cardiovascular risk who ware taking a stable daily dose of one of several statin medications for >=6 weeks prior to the study randomisation visit entered a 6-week open-label stabilisation/screening period during which they continued to receive their prestudy statin dose. Following stratification by study site and statin dose/porency, patients were randomise do EZE/SIMVA 10/20 mg (n=314 or ROSUVA 10 mg (n=304) for 6 weeks. Conclusion: EZE/SIMVA 10/20 mg produced greater improvements in LDL-C, total cholesterol, non-HDL-C and apoB with a similar safety profile as for ROSUVA 10 mg.

Název v anglickém jazyce

Lipid-Altering efficacy of ezetimibe/simvastatin 10/20 mg compared with rosuvastatin 10 mg in high-risk hypercholesterolemic patients inadequately controlled with prior statin monotherapy - the IN-CROSS study

Popis výsledku anglicky

To evaluate the efficacy of switching from a previous statin monotherapy to ezetimibe/simvastatin (EZE/SIMVA) 10/20 mg vs. rosuvastatin (ROSUVA) 10 mg. In this randomised, double-blind study, 618 patients with documented hypercholesterolaemia (low-density lipoprotein cholesterol /LDL-C/ >=2.59 and <=4.92 mmol/l) and with high cardiovascular risk who ware taking a stable daily dose of one of several statin medications for >=6 weeks prior to the study randomisation visit entered a 6-week open-label stabilisation/screening period during which they continued to receive their prestudy statin dose. Following stratification by study site and statin dose/porency, patients were randomise do EZE/SIMVA 10/20 mg (n=314 or ROSUVA 10 mg (n=304) for 6 weeks. Conclusion: EZE/SIMVA 10/20 mg produced greater improvements in LDL-C, total cholesterol, non-HDL-C and apoB with a similar safety profile as for ROSUVA 10 mg.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The international journal of clinical practice

ISSN

1368-5031

e-ISSN

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Svazek periodika

63

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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