Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009787" target="_blank" >RIV/61989592:15110/09:00009787 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus

Popis výsledku v původním jazyce

Aims: Tacrolimus and cyclosporine A (CyA) are cornerstones in immunosuppressive therapy. Cyclosporine side effects include hypertension and hypercholesterolemia both of which may increase the risk of cardiovascular mortality, gingival hyperplasia and hirsutism are known to reduce quality of life. The aim of this prespective study was to evaluate changes in cardiovascular risk profile and cosmetic side effects after conversion from CyA to tacrolimus. Methods: 25 stable kidney transplant recipients (9 male, 16 female) were converted froma a CyA to a tacrolimus - based regimen. Mean age was 45,7 +- 13,5 years. Time to switch following transplantation was 4,8+-1,7 years. Resons for conversion were multiple: arterial hypertension (9), hypertrichosis (3), gingival hyperplasia (3), hyperlipidemia (14). Results: 19/25 patients completed the one year study period. One patient died, two returned to hemodialysis. two were switched back to CyA and one patient was lost to follow-up. there were stat

Název v anglickém jazyce

Improvement of cardiovascular risk factors and cosmetic side effects in kidney transplant recipients after conversion to tacrolimus

Popis výsledku anglicky

Aims: Tacrolimus and cyclosporine A (CyA) are cornerstones in immunosuppressive therapy. Cyclosporine side effects include hypertension and hypercholesterolemia both of which may increase the risk of cardiovascular mortality, gingival hyperplasia and hirsutism are known to reduce quality of life. The aim of this prespective study was to evaluate changes in cardiovascular risk profile and cosmetic side effects after conversion from CyA to tacrolimus. Methods: 25 stable kidney transplant recipients (9 male, 16 female) were converted froma a CyA to a tacrolimus - based regimen. Mean age was 45,7 +- 13,5 years. Time to switch following transplantation was 4,8+-1,7 years. Resons for conversion were multiple: arterial hypertension (9), hypertrichosis (3), gingival hyperplasia (3), hyperlipidemia (14). Results: 19/25 patients completed the one year study period. One patient died, two returned to hemodialysis. two were switched back to CyA and one patient was lost to follow-up. there were stat

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/NS9964" target="_blank" >NS9964: Oxidační stres a antioxidační mechanismy po transplantaci ledviny</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

153

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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