POTENTIAL MARKERS OF INSULIN RESISTANCE IN HEALTHY VS OBESE AND OVERWEIGHT SUBJECTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10213554" target="_blank" >RIV/61989592:15110/10:10213554 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

POTENTIAL MARKERS OF INSULIN RESISTANCE IN HEALTHY VS OBESE AND OVERWEIGHT SUBJECTS

Popis výsledku v původním jazyce

Background. Insulin resistance can lead to the metabolic syndrome, which may have cardiovascular and metabolic consequences. The study aimed at verifying the serum concentration levels of the adipose tissue proteins adiponectin,adipocyte-fatty acid binding protein (a-FABP) and acylation stimulating protein (ASP), and the potential use of these markers for early diagnosis of insulin resistance. Methods and results. Healthy subjects (Group A, n = 53), overweight subjects (Group B, n = 29) and obese subjects(Group C, n = 51) were studied. The subjects were selected based on clinical and laboratory findings. Conclusions. The concentrations of all studied markers were different in the healthy subjects as compared to the overweight or obese ones. Adiponectinproved to be a good indicator of insulin sensitivity, the low concentration of which could signal the initial stage of insulin resistance. A-FABP proved to be a prominent marker of ?adiposity? in association with the development of insul

Název v anglickém jazyce

POTENTIAL MARKERS OF INSULIN RESISTANCE IN HEALTHY VS OBESE AND OVERWEIGHT SUBJECTS

Popis výsledku anglicky

Background. Insulin resistance can lead to the metabolic syndrome, which may have cardiovascular and metabolic consequences. The study aimed at verifying the serum concentration levels of the adipose tissue proteins adiponectin,adipocyte-fatty acid binding protein (a-FABP) and acylation stimulating protein (ASP), and the potential use of these markers for early diagnosis of insulin resistance. Methods and results. Healthy subjects (Group A, n = 53), overweight subjects (Group B, n = 29) and obese subjects(Group C, n = 51) were studied. The subjects were selected based on clinical and laboratory findings. Conclusions. The concentrations of all studied markers were different in the healthy subjects as compared to the overweight or obese ones. Adiponectinproved to be a good indicator of insulin sensitivity, the low concentration of which could signal the initial stage of insulin resistance. A-FABP proved to be a prominent marker of ?adiposity? in association with the development of insul

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NT11098" target="_blank" >NT11098: Epidemiologická studie významu proteinů tukové tkáně ve vztahu k inzulínové rezistenci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

154(3)

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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