Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

Kód výsledku v IS VaVaI

RIV/61989592:15110/11:10222123 - isvavai.cz

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

Popis výsledku v původním jazyce

UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, "non-skin" tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver.Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in pla

Název v anglickém jazyce

Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice

Popis výsledku anglicky

UV light is known to be implicated in several skin diseases. Through low molecular weight mediators, "non-skin" tissues can also be affected. Female SKH-1 mice were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)). Effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of GSH, oxidative damage markers were analysed in blood, liver and skin. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h after UVA and UVB irradiation, which disappeared within 24 h except for the higher UVA dose. Changes in activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products were found in skin, erythrocytes and liver.Expression of CAT, SOD, glutathione transferase, nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase and hem oxygenase-1 in skin was affected after UVA and UVB radiation. Increase in carbonylated proteins was found in pla

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

GP303/07/P314: Fotoprotektivní účinky přírodních látek na modelech in vitro a in vivo

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological & Pharmaceutical Bulletin

ISSN

0918-6158

e-ISSN

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Svazek periodika

34

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

9

Strana od-do

471-479

Kód UT WoS článku

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EID výsledku v databázi Scopus

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