Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223785" target="_blank" >RIV/61989592:15110/11:10223785 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >http://dx.doi.org/10.1007/s10735-011-9363-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10735-011-9363-1" target="_blank" >10.1007/s10735-011-9363-1</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos
Popis výsledku v původním jazyce
Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistence (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated.The organ-and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs.The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during I
Název v anglickém jazyce
Differential expression of ABC transporters ( MDR1, MRP1, BCRP) in developing human embryos
Popis výsledku anglicky
Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistence (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated.The organ-and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs.The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during I
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Molecular Histology
ISSN
1567-2379
e-ISSN
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Svazek periodika
42
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
8
Strana od-do
567-574
Kód UT WoS článku
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EID výsledku v databázi Scopus
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