Spatio-temporal expression of Peroxisome Proliferator-Activated Receptor a During Human Prenatal Development
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33152398" target="_blank" >RIV/61989592:15110/15:33152398 - isvavai.cz</a>
Výsledek na webu
<a href="http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12326/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/bcpt.12326/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.12326" target="_blank" >10.1111/bcpt.12326</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Spatio-temporal expression of Peroxisome Proliferator-Activated Receptor a During Human Prenatal Development
Popis výsledku v původním jazyce
Peroxisome proliferator-activated receptor a (PPARa) is a ligand-dependent transcription factor which is activated by various endogenous as well as exogenous compounds. It is involved in the regulation of a variety of biological processes, such as nutrient metabolism, energy homoeostasis, immunological response and xenobiotic metabolism. Little is known about its expression during human prenatal development. We examined the spatio-temporal expression pattern of PPARa in human embryonic/foetal intestines, liver and kidney from the 5th to 20th week of prenatal life by indirect two-step immunohistochemistry. PPARa expression can already be detected in the early stages of prenatal development; as early as the 7th week of intrauterine development (IUD) in the intestines, 5th week of IUD in the liver and 6th week of IUD in the kidney. We found agedependent changes in the PPARa expression pattern in the intestines and kidney. These events occur approximately at the commencement of function of
Název v anglickém jazyce
Spatio-temporal expression of Peroxisome Proliferator-Activated Receptor a During Human Prenatal Development
Popis výsledku anglicky
Peroxisome proliferator-activated receptor a (PPARa) is a ligand-dependent transcription factor which is activated by various endogenous as well as exogenous compounds. It is involved in the regulation of a variety of biological processes, such as nutrient metabolism, energy homoeostasis, immunological response and xenobiotic metabolism. Little is known about its expression during human prenatal development. We examined the spatio-temporal expression pattern of PPARa in human embryonic/foetal intestines, liver and kidney from the 5th to 20th week of prenatal life by indirect two-step immunohistochemistry. PPARa expression can already be detected in the early stages of prenatal development; as early as the 7th week of intrauterine development (IUD) in the intestines, 5th week of IUD in the liver and 6th week of IUD in the kidney. We found agedependent changes in the PPARa expression pattern in the intestines and kidney. These events occur approximately at the commencement of function of
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EA - Morfologické obory a cytologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Basic & Clinical Pharmacology & Toxicology
ISSN
1742-7835
e-ISSN
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Svazek periodika
116
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
361-366
Kód UT WoS článku
000351367600011
EID výsledku v databázi Scopus
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