Soluble intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in asymptomatic dyslipidemic subjects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A33116416" target="_blank" >RIV/61989592:15110/11:33116416 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/11:#0000336

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Soluble intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in asymptomatic dyslipidemic subjects

Popis výsledku v původním jazyce

The plasma levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were assessed in clinically asymptomatic subjects to compare them between normolipidemic and various dyslipidemic phenotypes. The associations between soluble cell adhesion molecules (sCAM-s) and risk factors for atherosclerosis, markers of insulin resistance, and the intima-media thickness of the common carotid artery (IMT) were evalouated, too. The elevation of s-ICAM_1was presented only in patients with simultaneously elevated TG and apoB (DLP4) in comparison with normolipidemic subjects. Patients with DLP4 had significantly increased IMT, which was independently predicted by levels of s-ICAM-1 and of s-VCAM-1. Thesefindings pointed out DLP4 subjects as individuals with the highest risk for early manifestation of atherosclerosis.

Název v anglickém jazyce

Soluble intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in asymptomatic dyslipidemic subjects

Popis výsledku anglicky

The plasma levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were assessed in clinically asymptomatic subjects to compare them between normolipidemic and various dyslipidemic phenotypes. The associations between soluble cell adhesion molecules (sCAM-s) and risk factors for atherosclerosis, markers of insulin resistance, and the intima-media thickness of the common carotid artery (IMT) were evalouated, too. The elevation of s-ICAM_1was presented only in patients with simultaneously elevated TG and apoB (DLP4) in comparison with normolipidemic subjects. Patients with DLP4 had significantly increased IMT, which was independently predicted by levels of s-ICAM-1 and of s-VCAM-1. Thesefindings pointed out DLP4 subjects as individuals with the highest risk for early manifestation of atherosclerosis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NS10284" target="_blank" >NS10284: Dyslipidémie a prehypertenze - asociace dyslipidemických fenotypů s výskytem prehypertenze. Asociace prehypertenze s markery inzulínové rezistence, zánětu, endoteliálni dysfunkce, trombózy a subklinické aterosklerózy.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Angiology

ISSN

0392-9590

e-ISSN

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Svazek periodika

30

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

10

Strana od-do

441-450

Kód UT WoS článku

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EID výsledku v databázi Scopus

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