Solubilní adhezivní molekuly S-VCAM-1 a S-ICAM-1 u osob s familiární kombinovanou hyperlipidemií

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001957" target="_blank" >RIV/61989592:15110/05:00001957 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Soluble cell adhesion molecules S-VCAM-1 and S-ICAM-1 in subjects with familial combined hyperlipidemia

Popis výsledku v původním jazyce

Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk for early atherosclerosis. The aim of this study was to compare levels of soluble intercellular cell adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) in asymptomatic members of FCH families with healthy controls and to determine the relation between s-ICAM-1, s-VCAM-1 and risk factors accompanying FCH. We also investigated the association between adhesion molecules andthe intima-media thickness (IMT) of the common carotid artery, a recognized morphological marker of early atherosclerosis. 82 members of 29 FCH families were divided into the 2 groups: HL (probands and hyperlipidemic first-degree relatives, n=47) and NL(normolipidemic first-degree relatives, n=35). The control groups - HL-C (n=20) and NL-C (n=20) - consisted of sex- and age- matched healthy individuals. Hyperlipidemic members had significantly higher concentration of s-ICAM-1 (633+/-169

Název v anglickém jazyce

Soluble cell adhesion molecules S-VCAM-1 and S-ICAM-1 in subjects with familial combined hyperlipidemia

Popis výsledku anglicky

Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk for early atherosclerosis. The aim of this study was to compare levels of soluble intercellular cell adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) in asymptomatic members of FCH families with healthy controls and to determine the relation between s-ICAM-1, s-VCAM-1 and risk factors accompanying FCH. We also investigated the association between adhesion molecules andthe intima-media thickness (IMT) of the common carotid artery, a recognized morphological marker of early atherosclerosis. 82 members of 29 FCH families were divided into the 2 groups: HL (probands and hyperlipidemic first-degree relatives, n=47) and NL(normolipidemic first-degree relatives, n=35). The control groups - HL-C (n=20) and NL-C (n=20) - consisted of sex- and age- matched healthy individuals. Hyperlipidemic members had significantly higher concentration of s-ICAM-1 (633+/-169

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

149

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

101-108

Kód UT WoS článku

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EID výsledku v databázi Scopus

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